We report the synthesis of N-15 enriched 2-aminopurine-2kleoxynucleoside (AMR). Both ring and 2-amino nitrogens were labelled via a Dimroth rearrangement of the free base. The corresponding deoxynucleoside was prepared enzymatically. Results of both proton and N-15 NMR studies show that the predominant tautomeric form of APdR is amino and the Ni position is sham to be the site of protonation.
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