Preparation of Imino and Amino N-15 Enriched 2-Aminopurine Deoxynucleoside

Lawrence C. Sowers, Dhananjaya N. Mhaskar, Tasneem A. Khwaja, Myron F. Goodman

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We report the synthesis of N-15 enriched 2-aminopurine-2kleoxynucleoside (AMR). Both ring and 2-amino nitrogens were labelled via a Dimroth rearrangement of the free base. The corresponding deoxynucleoside was prepared enzymatically. Results of both proton and N-15 NMR studies show that the predominant tautomeric form of APdR is amino and the Ni position is sham to be the site of protonation.

Original languageEnglish (US)
Pages (from-to)23-34
Number of pages12
JournalNucleosides and Nucleotides
Volume8
Issue number1
DOIs
StatePublished - Jan 1989

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ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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