Prepregnancy obesity and sFlt1-induced preeclampsia in mice

Developmental programming model of metabolic syndrome

Egle Bytautiene, Esther Tamayo, Talar Kechichian, Nathan Drever, Phyllis Gamble, Gary Hankins, George Saade

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: We sought to establish a model of fetal programming of metabolic syndrome by exposure to soluble fms-like tyrosine kinase-1 (sFlt1)-induced preeclampsia (PE) and preexisting maternal obesity (MO). Study design: CD-1 female mice were placed on either standard or high-fat diet for 3 months. On day 8 of pregnancy, mice were injected with either adenovirus-carrying sFlt1 or adenovirus-carrying murine immunoglobulin G2α Fc fragment. Offspring were studied at 6 months of age. Results: Exposure to MO with/without PE resulted in significant increase in progeny's weight and adiposity. Blood pressure in males was significantly increased due to MO with PE. Metabolic blood analytes were affected in males and females exposed to only PE or MO with/without PE; inflammatoryin females exposed to MO with/without PE and males born to MO with PE; atheroscleroticin females exposed to MO. Conclusion: Exposure to maternal prepregnancy obesity and sFlt1-induced preeclampsia alter the offspring's blood pressure, metabolic, inflammatory, and atherosclerotic profiles later in life.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume204
Issue number5
DOIs
StatePublished - May 2011

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Vascular Endothelial Growth Factor Receptor-1
Pre-Eclampsia
Obesity
Mothers
Maternal Exposure
Adenoviridae
Blood Pressure
Immunoglobulin Fc Fragments
Adiposity
High Fat Diet
Fetal Development
Weights and Measures
Pregnancy

Keywords

  • metabolic syndrome
  • mice
  • obesity
  • offspring
  • preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Prepregnancy obesity and sFlt1-induced preeclampsia in mice : Developmental programming model of metabolic syndrome. / Bytautiene, Egle; Tamayo, Esther; Kechichian, Talar; Drever, Nathan; Gamble, Phyllis; Hankins, Gary; Saade, George.

In: American Journal of Obstetrics and Gynecology, Vol. 204, No. 5, 05.2011.

Research output: Contribution to journalArticle

Bytautiene, Egle ; Tamayo, Esther ; Kechichian, Talar ; Drever, Nathan ; Gamble, Phyllis ; Hankins, Gary ; Saade, George. / Prepregnancy obesity and sFlt1-induced preeclampsia in mice : Developmental programming model of metabolic syndrome. In: American Journal of Obstetrics and Gynecology. 2011 ; Vol. 204, No. 5.
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