Presentation of atopic disease in a large cohort of pediatric liver transplant recipients

P. Shroff, R. S. Mehta, J. Chinen, S. J. Karpen, C. M. Davis

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Atopic disease occurs in solid organ transplant recipients with an increasingly recognized frequency. The time course for the development of these atopic diseases in liver transplantation has not been described. The objective was to characterize the atopic manifestations of children receiving chronic immunosuppression after orthotopic liver transplantation (OLT). Chart review and follow-up questionnaire were utilized for 176 OLT pediatric recipients at a single institution for manifestations of allergic disease. Atopic disease was present in 25 (14.2%) patients. Median age at transplant was 16 months with a median follow-up of 63 months. Food allergy and non-food related atopic symptoms presented at a median of 11.5 (IQR, 6-28) and 19 (IQR, 5-41) months post-transplantation, respectively. The median age at transplant of the non-atopic children was 72 months, higher than patients with atopy (p < 0.001). Food allergy and atopic skin disease symptoms were present in 40% and 56% of cases, respectively. Asthma, allergic rhinitis, or both were found in 66% of cases. The onset of symptoms of food allergy and eczema (median, 12 months post-transplantation) preceded symptoms of allergic rhinitis and asthma. (median of 27 and 30 months post-transplantation, respectively). Atopy occurs in ∼14% of pediatric liver transplant recipients, with manifestations including food allergy, eczema, allergic rhinitis, and asthma.

Original languageEnglish (US)
Pages (from-to)379-384
Number of pages6
JournalPediatric Transplantation
Volume16
Issue number4
DOIs
StatePublished - Jun 2012

Fingerprint

Food Hypersensitivity
Liver Transplantation
Pediatrics
Asthma
Transplantation
Liver
Eczema
Transplants
Skin Diseases
Immunosuppression
Transplant Recipients
Allergic Rhinitis

Keywords

  • pediatric liver transplantation
  • tacrolimus
  • tolerance

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Presentation of atopic disease in a large cohort of pediatric liver transplant recipients. / Shroff, P.; Mehta, R. S.; Chinen, J.; Karpen, S. J.; Davis, C. M.

In: Pediatric Transplantation, Vol. 16, No. 4, 06.2012, p. 379-384.

Research output: Contribution to journalArticle

Shroff, P. ; Mehta, R. S. ; Chinen, J. ; Karpen, S. J. ; Davis, C. M. / Presentation of atopic disease in a large cohort of pediatric liver transplant recipients. In: Pediatric Transplantation. 2012 ; Vol. 16, No. 4. pp. 379-384.
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