Presentation of venous thromboembolism during pregnancy

A. G. Witlin, F. M. Mattar, George Saade, J. W. Van Hook, B. M. Sibai

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

OBJECTIVE: We sought to characterize the presentation, recurrence, and outcome of venous thromboembolism during pregnancy. STUDY DESIGN: We performed a 12-year, single-center, retrospective review of 38 patients with venous thromboembolism during pregnancy. The independent variables were subjected to univariate analysis (unpaired t test for normally distributed continuous variables and Fisher exact test for discrete variables). P < .05 was considered significant. RESULTS: There was no significant difference for the following variables according to time of presentation (antepartum vs post partum): gestational age at delivery (37.4 ± 6.6 wk vs 38.1 ± 2.4 wk; P = .7), birth weight (3257 ± 458 g vs 3093 ± 719 g; P = .3), and mode of delivery (2 vs 4 cesarean deliveries; P = .15). There were 2 maternal deaths. All 3 women with antepartum recurrent venous thromboembolism (despite heparin prophylaxis) had findings of protein C deficiency, protein S deficiency, and lupus anticoagulant-anticardiolipin antibody, respectively. CONCLUSION: The gestational age at presentation appears more equally distributed throughout gestation than previously reported. Notwithstanding limited numbers, the recurrence of venous thromboembolism despite use of prophylactic heparin therapy suggests the need to reexamine the current recommendations for heparin dosing.

Original languageEnglish (US)
Pages (from-to)1118-1121
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume181
Issue number5 I
DOIs
StatePublished - 1999

Fingerprint

Venous Thromboembolism
Heparin
Pregnancy
Gestational Age
Protein S Deficiency
Protein C Deficiency
Recurrence
Lupus Coagulation Inhibitor
Anticardiolipin Antibodies
Maternal Death
Birth Weight
Therapeutics

Keywords

  • Heparin
  • Pregnancy
  • Thromboembolism

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Presentation of venous thromboembolism during pregnancy. / Witlin, A. G.; Mattar, F. M.; Saade, George; Van Hook, J. W.; Sibai, B. M.

In: American Journal of Obstetrics and Gynecology, Vol. 181, No. 5 I, 1999, p. 1118-1121.

Research output: Contribution to journalArticle

Witlin, A. G. ; Mattar, F. M. ; Saade, George ; Van Hook, J. W. ; Sibai, B. M. / Presentation of venous thromboembolism during pregnancy. In: American Journal of Obstetrics and Gynecology. 1999 ; Vol. 181, No. 5 I. pp. 1118-1121.
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