Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals

Pietro Scaduto, Adolfo Sequeira, Marquis P. Vawter, William Bunney, Agenor Limon

Research output: Contribution to journalArticle

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Abstract

The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120 h after death, expanding the availability and use of human diseased tissue stored in brain banks.

Original languageEnglish (US)
Article number8626
JournalScientific reports
Volume10
Issue number1
DOIs
StatePublished - Dec 1 2020

ASJC Scopus subject areas

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