Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals

Pietro Scaduto; Adolfo Sequeira; Marquis P. Vawter; William Bunney; Agenor Limon

doi:10.1038/s41598-020-65377-3

Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals

Pietro Scaduto, Adolfo Sequeira, Marquis P. Vawter, William Bunney, Agenor Limon

Neurology

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7 Scopus citations

Abstract

The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120 h after death, expanding the availability and use of human diseased tissue stored in brain banks.

Original language	English (US)
Article number	8626
Journal	Scientific reports
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41598-020-65377-3
State	Published - Dec 1 2020

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abstract = "The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120 h after death, expanding the availability and use of human diseased tissue stored in brain banks.",

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AU - Sequeira, Adolfo

AU - Vawter, Marquis P.

AU - Bunney, William

AU - Limon, Agenor

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AB - The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120 h after death, expanding the availability and use of human diseased tissue stored in brain banks.

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Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals

Abstract

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