Pressor response to beta-blocking drugs

M. G. Ziegler, L. C. Woodson

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations


    A patient with essential hypertension had a prolonged period of uncontrollable high blood pressure during therapy with the nonspecific beta-blocker nadolol. A subsequent challenge with the beta1-blocker atenolol caused a pressor response associated with diminished catecholamine release, impaired catecholamine clearance, loss of baroreflex response, and bradycardia. Beta-blocking drugs can lead to hypertension by causing fluid retention, reversal of catecholamine vasodilatation, or a direct pressor effect.

    Original languageEnglish (US)
    Pages (from-to)81-88
    Number of pages8
    JournalClinical Therapeutics
    Issue number1
    StatePublished - Dec 1 1984

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)


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