Preterm birth and its long-term effects: Methylation to mechanisms

Sasha E. Parets, Carrie E. Bedient, Ramkumar Menon, Alicia K. Smith

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


The epigenetic patterns established during development may influence gene expression over a lifetime and increase susceptibility to chronic disease. Being born preterm (<37 weeks of gestation) is associated with increased risk mortality and morbidity from birth until adulthood. This brief review explores the potential role of DNA methylation in preterm birth (PTB) and its possible long-term consequences and provides an overview of the physiological processes central to PTB and recent DNA methylation studies of PTB.

Original languageEnglish (US)
Pages (from-to)498-513
Number of pages16
Issue number3
StatePublished - Aug 21 2014


  • DNA methylation
  • DOHaD
  • Developmental programming
  • Epigenetic
  • Gestational age
  • Pregnancy
  • Preterm birth

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences


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