Preterm birth and its long-term effects: Methylation to mechanisms

Sasha E. Parets, Carrie E. Bedient, Ramkumar Menon, Alicia K. Smith

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The epigenetic patterns established during development may influence gene expression over a lifetime and increase susceptibility to chronic disease. Being born preterm (<37 weeks of gestation) is associated with increased risk mortality and morbidity from birth until adulthood. This brief review explores the potential role of DNA methylation in preterm birth (PTB) and its possible long-term consequences and provides an overview of the physiological processes central to PTB and recent DNA methylation studies of PTB.

Original languageEnglish (US)
Pages (from-to)498-513
Number of pages16
JournalBiology
Volume3
Issue number3
DOIs
StatePublished - Aug 21 2014

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Keywords

  • Developmental programming
  • DNA methylation
  • DOHaD
  • Epigenetic
  • Gestational age
  • Pregnancy
  • Preterm birth

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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