Preterm birth and its long-term effects: Methylation to mechanisms

Sasha E. Parets; Carrie E. Bedient; Ramkumar Menon; Alicia K. Smith

doi:10.3390/biology3030498

Preterm birth and its long-term effects: Methylation to mechanisms

Sasha E. Parets, Carrie E. Bedient, Ramkumar Menon, Alicia K. Smith

Obstetrics & Gynecology

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

The epigenetic patterns established during development may influence gene expression over a lifetime and increase susceptibility to chronic disease. Being born preterm (<37 weeks of gestation) is associated with increased risk mortality and morbidity from birth until adulthood. This brief review explores the potential role of DNA methylation in preterm birth (PTB) and its possible long-term consequences and provides an overview of the physiological processes central to PTB and recent DNA methylation studies of PTB.

Original language	English (US)
Pages (from-to)	498-513
Number of pages	16
Journal	Biology
Volume	3
Issue number	3
DOIs	https://doi.org/10.3390/biology3030498
State	Published - Aug 21 2014

Keywords

DNA methylation
DOHaD
Developmental programming
Epigenetic
Gestational age
Pregnancy
Preterm birth

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences

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10.3390/biology3030498

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abstract = "The epigenetic patterns established during development may influence gene expression over a lifetime and increase susceptibility to chronic disease. Being born preterm (<37 weeks of gestation) is associated with increased risk mortality and morbidity from birth until adulthood. This brief review explores the potential role of DNA methylation in preterm birth (PTB) and its possible long-term consequences and provides an overview of the physiological processes central to PTB and recent DNA methylation studies of PTB.",

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AU - Menon, Ramkumar

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PY - 2014/8/21

Y1 - 2014/8/21

N2 - The epigenetic patterns established during development may influence gene expression over a lifetime and increase susceptibility to chronic disease. Being born preterm (<37 weeks of gestation) is associated with increased risk mortality and morbidity from birth until adulthood. This brief review explores the potential role of DNA methylation in preterm birth (PTB) and its possible long-term consequences and provides an overview of the physiological processes central to PTB and recent DNA methylation studies of PTB.

AB - The epigenetic patterns established during development may influence gene expression over a lifetime and increase susceptibility to chronic disease. Being born preterm (<37 weeks of gestation) is associated with increased risk mortality and morbidity from birth until adulthood. This brief review explores the potential role of DNA methylation in preterm birth (PTB) and its possible long-term consequences and provides an overview of the physiological processes central to PTB and recent DNA methylation studies of PTB.

KW - DNA methylation

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KW - Developmental programming

KW - Epigenetic

KW - Gestational age

KW - Pregnancy

KW - Preterm birth

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Preterm birth and its long-term effects: Methylation to mechanisms

Abstract

Keywords

ASJC Scopus subject areas

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