Preterm birth and its long-term effects: Methylation to mechanisms

Sasha E. Parets, Carrie E. Bedient, Ramkumar Menon, Alicia K. Smith

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

The epigenetic patterns established during development may influence gene expression over a lifetime and increase susceptibility to chronic disease. Being born preterm (<37 weeks of gestation) is associated with increased risk mortality and morbidity from birth until adulthood. This brief review explores the potential role of DNA methylation in preterm birth (PTB) and its possible long-term consequences and provides an overview of the physiological processes central to PTB and recent DNA methylation studies of PTB.

Original languageEnglish (US)
Pages (from-to)498-513
Number of pages16
JournalBiology
Volume3
Issue number3
DOIs
StatePublished - Aug 21 2014

Keywords

  • DNA methylation
  • DOHaD
  • Developmental programming
  • Epigenetic
  • Gestational age
  • Pregnancy
  • Preterm birth

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

Fingerprint Dive into the research topics of 'Preterm birth and its long-term effects: Methylation to mechanisms'. Together they form a unique fingerprint.

Cite this