@article{c0e36bfb358f485f8a133dbb9201113d,
title = "Preterm birth update in Australasia: A report of the international symposium of Preterm Birth International Collaborative-Australasia branch",
abstract = "Preterm birth (PTB) is one of the most important problems that pose dilemmas for both the obstetrician and neonatologist, placing a heavy burden psychologically and financially on the families involved, and triggering high socio-economic costs to the public healthcare. The rate of PTB in Asian countries has been ranked at top globally. To reduce the PTB rate, to promote the prevention and intervention for PTB, and to better understand the pathophysiology underlying PTB, the Preterm Birth International Collaborative Australia branch (PREBIC-AA) was launched in 2017. A series scientific activities including organizing annual research symposiums has been planned and organized among Australasian countries. Here we briefly updated the current progress in clinical management and translational research on PTB in Australasian countries that have been participated in PREBIC-AA.",
keywords = "Australia, maternal and children's health, PREBIC, preterm birth, symposium report",
author = "Chong Qiao and Ramkumar Menon and Ahn, {Ki Hoon} and Shunji Suzuki and Pallavi Kshetrapal and Georgiou, {Harry Michael} and Sam Mesiano and Nanbert Zhong",
note = "Funding Information: Group of Advanced Outcome and Research a DBT India initiative (Garbh-ini), an observational tertiary hospital-based pregnancy cohort in the North of India, funded by the Department of Biotechnology, Ministry of Science and Technology, was presented to discovery of molecular signatures of PTB using integrated multi-omic approaches. The cohort has reported proteomic changes in maternal saliva, and high vaginal fluid obtained serially along pregnancy, using the state-of-the-art label-free proteomics (SWATH-MS) approach. Detailed protein-protein interaction network analysis has revealed a list of proteins associated with maternal immune modulation, metabolism, host defense mechanism and tissue remodeling, organ development microbial defense in salivary and high vaginal fluid analysis respectively (, ). Toward mechanistic studies, placental derived exosomes isolated from maternal plasma sampled at three different trimesters and delivery were profiled across pregnancy for their protein cargo. Computational analysis of differentially expressed proteins revealed consistent upregulation of inflammatory pathways in term and preterm delivery mothers, upregulation of epithelial-mesenchymal transition pathways in term, and downregulation of coagulation/complement activation in PTB samples (). Publisher Copyright: Copyright {\textcopyright} 2022 Qiao, Menon, Ahn, Suzuki, Kshetrapal, Georgiou, Mesiano and Zhong.",
year = "2022",
month = jul,
day = "25",
doi = "10.3389/fped.2022.903546",
language = "English (US)",
volume = "10",
journal = "Frontiers in Pediatrics",
issn = "2296-2360",
publisher = "Frontiers Media S. A.",
}