Prevalence of antibodies against Rift Valley fever virus in Kenyan wildlife

A. Evans, F. Gakuya, J. T. Paweska, M. Rostal, L. Akoolo, P. J. Van Vuren, T. Manyibe, J. M. Macharia, Thomas Ksiazek, D. R. Feikin, R. F. Breiman, M. Kariuki Njenga

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Abstract

Rift Valley fever virus (RVFV) is an arbovirus associated with periodic outbreaks, mostly on the African continent, of febrile disease accompanied by abortion in livestock, and a severe, fatal haemorrhagic syndrome in humans. However, the maintenance of the virus during the inter-epidemic period (IEP) when there is low or no disease activity detected in livestock or humans has not been determined. This study report prevalence of RVFV-neutralizing antibodies in sera (n=896) collected from 16 Kenyan wildlife species including at least 35% that were born during the 1999-2006 IEP. Specimens from seven species had detectable neutralizing antibodies against RVFV, including African buffalo, black rhino, lesser kudu, impala, African elephant, kongoni, and waterbuck. High RVFV antibody prevalence (>15%) was observed in black rhinos and ruminants (kudu, impala, buffalo, and waterbuck) with the highest titres (up to 1:1280) observed mostly in buffalo, including animals born during the IEP. All lions, giraffes, plains zebras, and warthogs tested were either negative or less than two animals in each species had low (≤1:16) titres of RVFV antibodies. Of 249 sera collected from five wildlife species during the 2006-2007 outbreak, 16 out of 19 (84%) of the ruminant (gerenuk, waterbuck, and eland) specimens had RVFV-neutralizing titres ≥1:80. These data provide evidence that wild ruminants are infected by RVFV but further studies are required to determine whether these animals play a role in the virus maintenance between outbreaks and virus amplification prior to a noticeable outbreak.

Original languageEnglish (US)
Pages (from-to)1261-1269
Number of pages9
JournalEpidemiology and Infection
Volume136
Issue number9
DOIs
StatePublished - Sep 2008
Externally publishedYes

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Rift Valley fever virus
Antibodies
Disease Outbreaks
Buffaloes
Ruminants
Livestock
Viruses
Neutralizing Antibodies
Maintenance
Lions
Arboviruses
Equidae
Viral Load
Serum
Fever
Swine
Cross-Sectional Studies

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Evans, A., Gakuya, F., Paweska, J. T., Rostal, M., Akoolo, L., Van Vuren, P. J., ... Kariuki Njenga, M. (2008). Prevalence of antibodies against Rift Valley fever virus in Kenyan wildlife. Epidemiology and Infection, 136(9), 1261-1269. https://doi.org/10.1017/S0950268807009806

Prevalence of antibodies against Rift Valley fever virus in Kenyan wildlife. / Evans, A.; Gakuya, F.; Paweska, J. T.; Rostal, M.; Akoolo, L.; Van Vuren, P. J.; Manyibe, T.; Macharia, J. M.; Ksiazek, Thomas; Feikin, D. R.; Breiman, R. F.; Kariuki Njenga, M.

In: Epidemiology and Infection, Vol. 136, No. 9, 09.2008, p. 1261-1269.

Research output: Contribution to journalArticle

Evans, A, Gakuya, F, Paweska, JT, Rostal, M, Akoolo, L, Van Vuren, PJ, Manyibe, T, Macharia, JM, Ksiazek, T, Feikin, DR, Breiman, RF & Kariuki Njenga, M 2008, 'Prevalence of antibodies against Rift Valley fever virus in Kenyan wildlife', Epidemiology and Infection, vol. 136, no. 9, pp. 1261-1269. https://doi.org/10.1017/S0950268807009806
Evans A, Gakuya F, Paweska JT, Rostal M, Akoolo L, Van Vuren PJ et al. Prevalence of antibodies against Rift Valley fever virus in Kenyan wildlife. Epidemiology and Infection. 2008 Sep;136(9):1261-1269. https://doi.org/10.1017/S0950268807009806
Evans, A. ; Gakuya, F. ; Paweska, J. T. ; Rostal, M. ; Akoolo, L. ; Van Vuren, P. J. ; Manyibe, T. ; Macharia, J. M. ; Ksiazek, Thomas ; Feikin, D. R. ; Breiman, R. F. ; Kariuki Njenga, M. / Prevalence of antibodies against Rift Valley fever virus in Kenyan wildlife. In: Epidemiology and Infection. 2008 ; Vol. 136, No. 9. pp. 1261-1269.
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abstract = "Rift Valley fever virus (RVFV) is an arbovirus associated with periodic outbreaks, mostly on the African continent, of febrile disease accompanied by abortion in livestock, and a severe, fatal haemorrhagic syndrome in humans. However, the maintenance of the virus during the inter-epidemic period (IEP) when there is low or no disease activity detected in livestock or humans has not been determined. This study report prevalence of RVFV-neutralizing antibodies in sera (n=896) collected from 16 Kenyan wildlife species including at least 35{\%} that were born during the 1999-2006 IEP. Specimens from seven species had detectable neutralizing antibodies against RVFV, including African buffalo, black rhino, lesser kudu, impala, African elephant, kongoni, and waterbuck. High RVFV antibody prevalence (>15{\%}) was observed in black rhinos and ruminants (kudu, impala, buffalo, and waterbuck) with the highest titres (up to 1:1280) observed mostly in buffalo, including animals born during the IEP. All lions, giraffes, plains zebras, and warthogs tested were either negative or less than two animals in each species had low (≤1:16) titres of RVFV antibodies. Of 249 sera collected from five wildlife species during the 2006-2007 outbreak, 16 out of 19 (84{\%}) of the ruminant (gerenuk, waterbuck, and eland) specimens had RVFV-neutralizing titres ≥1:80. These data provide evidence that wild ruminants are infected by RVFV but further studies are required to determine whether these animals play a role in the virus maintenance between outbreaks and virus amplification prior to a noticeable outbreak.",
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