Prevalence of antibodies to West Nile fever, sandfly fever Sicilian, and sandfly fever Naples viruses in healthy adults in Israel

Dani Cohen, Yona Zaide, Erik Karasenty, Mikael Schwarz, James LeDuc, Raphael Slepon, Thomas Ksiazek, Joshua Shemer, Manfred S. Green

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background: The arbovirus infections West Nile fever (WNF) and sandfly fever (SFF) are both endemic in the Middle East. Despite the fact that the mosquito and sandfly vectors of these viruses are still found in Israel, SFF has not been reported since 1948, whereas outbreaks of WNF occur periodically. It is suspected that some of the cases of nonspecific febrile illnesses in Israel may in fact be either WNF or SFF. Aim: To determine the extent of past arbovirus infections in subgroups of Israeli soldiers. Methods: Sera from random samples of three groups of healthy soldiers aged 18-20 (n=273), 21-30 (n=497), and 40-55 years (n=285) were examined for IgG and IgM antibodies to West Nile virus (WNV), sandfly fever Sicilian virus (SFSV), and sandfly fever Naples virus (SFNV), using an ELISA method. Results: The prevalence of antibodies increased with age for all three viruses examined, and ranged from 7.0%, 0, and 2.8%, for WNV, SFSV, and SFNV, respectively, in soldiers aged 18-20 years, to 41.9%, 23.7%, and 30.8%, in those aged 40-55 years. The percentage of seropositives for IgG who were also IgM positive were 1.0%, 5.9%, and 3.4%, for WNV, SFSV, and SFNV, respectively. 17.5% of the seropositives for WNV were also positive for SFSV, as compared with 5.7% among the WNV-seronegatives. Among the seropositives for WNV, 23.99% were positive for SFNV, compared with 9.1% of WNV seronegatives. 48.2% of seropositives for SFSV were positive for SFNV, as compared with 8.4% for SFSV-seronegatives. In the age group 40-55 years, there were significantly higher prevalence rates in those born in Israel compared with those born abroad. Conclusions: There is still significant exposure to WNV, SFSV, and SFNV in Israel. Arboviruses are probably responsible for many cases of non-specific febrile illness in this region.

Original languageEnglish (US)
Pages (from-to)217-230
Number of pages14
JournalPublic Health Reviews
Volume27
Issue number1-3
StatePublished - 1999
Externally publishedYes

Fingerprint

Sandfly fever Naples virus
Phlebotomus Fever
West Nile Fever
Phlebovirus
West Nile virus
Israel
Antibodies
Military Personnel
Arbovirus Infections
Immunoglobulin M
Fever
Immunoglobulin G
Viruses
Arboviruses
Psychodidae
Middle East
Disease Outbreaks
Age Groups
Enzyme-Linked Immunosorbent Assay

Keywords

  • Arboviruses
  • Sandfly fever viruses
  • Seroprevalence
  • West Nile virus

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Cohen, D., Zaide, Y., Karasenty, E., Schwarz, M., LeDuc, J., Slepon, R., ... Green, M. S. (1999). Prevalence of antibodies to West Nile fever, sandfly fever Sicilian, and sandfly fever Naples viruses in healthy adults in Israel. Public Health Reviews, 27(1-3), 217-230.

Prevalence of antibodies to West Nile fever, sandfly fever Sicilian, and sandfly fever Naples viruses in healthy adults in Israel. / Cohen, Dani; Zaide, Yona; Karasenty, Erik; Schwarz, Mikael; LeDuc, James; Slepon, Raphael; Ksiazek, Thomas; Shemer, Joshua; Green, Manfred S.

In: Public Health Reviews, Vol. 27, No. 1-3, 1999, p. 217-230.

Research output: Contribution to journalArticle

Cohen, D, Zaide, Y, Karasenty, E, Schwarz, M, LeDuc, J, Slepon, R, Ksiazek, T, Shemer, J & Green, MS 1999, 'Prevalence of antibodies to West Nile fever, sandfly fever Sicilian, and sandfly fever Naples viruses in healthy adults in Israel', Public Health Reviews, vol. 27, no. 1-3, pp. 217-230.
Cohen, Dani ; Zaide, Yona ; Karasenty, Erik ; Schwarz, Mikael ; LeDuc, James ; Slepon, Raphael ; Ksiazek, Thomas ; Shemer, Joshua ; Green, Manfred S. / Prevalence of antibodies to West Nile fever, sandfly fever Sicilian, and sandfly fever Naples viruses in healthy adults in Israel. In: Public Health Reviews. 1999 ; Vol. 27, No. 1-3. pp. 217-230.
@article{314a77e4c6f248a8a099efaa4f5602de,
title = "Prevalence of antibodies to West Nile fever, sandfly fever Sicilian, and sandfly fever Naples viruses in healthy adults in Israel",
abstract = "Background: The arbovirus infections West Nile fever (WNF) and sandfly fever (SFF) are both endemic in the Middle East. Despite the fact that the mosquito and sandfly vectors of these viruses are still found in Israel, SFF has not been reported since 1948, whereas outbreaks of WNF occur periodically. It is suspected that some of the cases of nonspecific febrile illnesses in Israel may in fact be either WNF or SFF. Aim: To determine the extent of past arbovirus infections in subgroups of Israeli soldiers. Methods: Sera from random samples of three groups of healthy soldiers aged 18-20 (n=273), 21-30 (n=497), and 40-55 years (n=285) were examined for IgG and IgM antibodies to West Nile virus (WNV), sandfly fever Sicilian virus (SFSV), and sandfly fever Naples virus (SFNV), using an ELISA method. Results: The prevalence of antibodies increased with age for all three viruses examined, and ranged from 7.0{\%}, 0, and 2.8{\%}, for WNV, SFSV, and SFNV, respectively, in soldiers aged 18-20 years, to 41.9{\%}, 23.7{\%}, and 30.8{\%}, in those aged 40-55 years. The percentage of seropositives for IgG who were also IgM positive were 1.0{\%}, 5.9{\%}, and 3.4{\%}, for WNV, SFSV, and SFNV, respectively. 17.5{\%} of the seropositives for WNV were also positive for SFSV, as compared with 5.7{\%} among the WNV-seronegatives. Among the seropositives for WNV, 23.99{\%} were positive for SFNV, compared with 9.1{\%} of WNV seronegatives. 48.2{\%} of seropositives for SFSV were positive for SFNV, as compared with 8.4{\%} for SFSV-seronegatives. In the age group 40-55 years, there were significantly higher prevalence rates in those born in Israel compared with those born abroad. Conclusions: There is still significant exposure to WNV, SFSV, and SFNV in Israel. Arboviruses are probably responsible for many cases of non-specific febrile illness in this region.",
keywords = "Arboviruses, Sandfly fever viruses, Seroprevalence, West Nile virus",
author = "Dani Cohen and Yona Zaide and Erik Karasenty and Mikael Schwarz and James LeDuc and Raphael Slepon and Thomas Ksiazek and Joshua Shemer and Green, {Manfred S.}",
year = "1999",
language = "English (US)",
volume = "27",
pages = "217--230",
journal = "Public Health Reviews",
issn = "0301-0422",
publisher = "EHESP Presses",
number = "1-3",

}

TY - JOUR

T1 - Prevalence of antibodies to West Nile fever, sandfly fever Sicilian, and sandfly fever Naples viruses in healthy adults in Israel

AU - Cohen, Dani

AU - Zaide, Yona

AU - Karasenty, Erik

AU - Schwarz, Mikael

AU - LeDuc, James

AU - Slepon, Raphael

AU - Ksiazek, Thomas

AU - Shemer, Joshua

AU - Green, Manfred S.

PY - 1999

Y1 - 1999

N2 - Background: The arbovirus infections West Nile fever (WNF) and sandfly fever (SFF) are both endemic in the Middle East. Despite the fact that the mosquito and sandfly vectors of these viruses are still found in Israel, SFF has not been reported since 1948, whereas outbreaks of WNF occur periodically. It is suspected that some of the cases of nonspecific febrile illnesses in Israel may in fact be either WNF or SFF. Aim: To determine the extent of past arbovirus infections in subgroups of Israeli soldiers. Methods: Sera from random samples of three groups of healthy soldiers aged 18-20 (n=273), 21-30 (n=497), and 40-55 years (n=285) were examined for IgG and IgM antibodies to West Nile virus (WNV), sandfly fever Sicilian virus (SFSV), and sandfly fever Naples virus (SFNV), using an ELISA method. Results: The prevalence of antibodies increased with age for all three viruses examined, and ranged from 7.0%, 0, and 2.8%, for WNV, SFSV, and SFNV, respectively, in soldiers aged 18-20 years, to 41.9%, 23.7%, and 30.8%, in those aged 40-55 years. The percentage of seropositives for IgG who were also IgM positive were 1.0%, 5.9%, and 3.4%, for WNV, SFSV, and SFNV, respectively. 17.5% of the seropositives for WNV were also positive for SFSV, as compared with 5.7% among the WNV-seronegatives. Among the seropositives for WNV, 23.99% were positive for SFNV, compared with 9.1% of WNV seronegatives. 48.2% of seropositives for SFSV were positive for SFNV, as compared with 8.4% for SFSV-seronegatives. In the age group 40-55 years, there were significantly higher prevalence rates in those born in Israel compared with those born abroad. Conclusions: There is still significant exposure to WNV, SFSV, and SFNV in Israel. Arboviruses are probably responsible for many cases of non-specific febrile illness in this region.

AB - Background: The arbovirus infections West Nile fever (WNF) and sandfly fever (SFF) are both endemic in the Middle East. Despite the fact that the mosquito and sandfly vectors of these viruses are still found in Israel, SFF has not been reported since 1948, whereas outbreaks of WNF occur periodically. It is suspected that some of the cases of nonspecific febrile illnesses in Israel may in fact be either WNF or SFF. Aim: To determine the extent of past arbovirus infections in subgroups of Israeli soldiers. Methods: Sera from random samples of three groups of healthy soldiers aged 18-20 (n=273), 21-30 (n=497), and 40-55 years (n=285) were examined for IgG and IgM antibodies to West Nile virus (WNV), sandfly fever Sicilian virus (SFSV), and sandfly fever Naples virus (SFNV), using an ELISA method. Results: The prevalence of antibodies increased with age for all three viruses examined, and ranged from 7.0%, 0, and 2.8%, for WNV, SFSV, and SFNV, respectively, in soldiers aged 18-20 years, to 41.9%, 23.7%, and 30.8%, in those aged 40-55 years. The percentage of seropositives for IgG who were also IgM positive were 1.0%, 5.9%, and 3.4%, for WNV, SFSV, and SFNV, respectively. 17.5% of the seropositives for WNV were also positive for SFSV, as compared with 5.7% among the WNV-seronegatives. Among the seropositives for WNV, 23.99% were positive for SFNV, compared with 9.1% of WNV seronegatives. 48.2% of seropositives for SFSV were positive for SFNV, as compared with 8.4% for SFSV-seronegatives. In the age group 40-55 years, there were significantly higher prevalence rates in those born in Israel compared with those born abroad. Conclusions: There is still significant exposure to WNV, SFSV, and SFNV in Israel. Arboviruses are probably responsible for many cases of non-specific febrile illness in this region.

KW - Arboviruses

KW - Sandfly fever viruses

KW - Seroprevalence

KW - West Nile virus

UR - http://www.scopus.com/inward/record.url?scp=0033499294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033499294&partnerID=8YFLogxK

M3 - Article

VL - 27

SP - 217

EP - 230

JO - Public Health Reviews

JF - Public Health Reviews

SN - 0301-0422

IS - 1-3

ER -