Prevalence of HHV-8 in cutaneous neoplasms

Angela Yen, Peter Rady, Allison Jones, Ida Orengo, Suzanne Bruce, Richard Wagner, Stephen K. Tyring

Research output: Contribution to journalArticle

Abstract

Recently, Human Herpes Virus 8 (HHV-8) has been proposed to be the putative virus in the development of Kaposi's sarcoma in AIDS patients (AIDS-KS). To identify the presence and prevalence of HHV-8 in lesions other than in AIDS-KS, PCR analysis for HHV-8 DNA sequences was performed on 13 samples of AIDS-KS, 18 samples of classic Kaposi's sarcoma (non-KS) proliferative skin lesions (basal cell carcinomas, squamous cell carcinomas, actinic keratoses, verruca vulgaris, atypical squamous proliferations, and seborrheic keratoses) from immunosuppressed organ transplant patients, and 7 samples of primary and 5 samples of recurrent basal cell (BCC) and squamous cell carcinomas (SCC) from immuno-competent patients. HHV-88 was detected in 100% of the AIDS-KS samples, 72% of the CKS samples, 100% of the OKS samples, 82% of the non-KS samples from organ transplant patients, 14% of the primary BCC and SCC from immunocompetent patients, and 40% of the recurrent BCC and SCC from immunocompetent patients. These results suggest that the recently discovered HHV-8 is associated with lesions besides AIDS-KS, with the prevalence of HHV-8 being highest in AIDS-KS and OKS. In addition, the prevalence of HHV-8 in these samples is greater in recurrent carcinoma than in primary carcinoma. These data also suggest that HHV-8 may be involved, albeit not solely responsible, in the pathogenesis of KS and carcinomas.

Original languageEnglish (US)
Pages (from-to)52A
JournalJournal of Investigative Medicine
Volume44
Issue number1
StatePublished - Jan 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Yen, A., Rady, P., Jones, A., Orengo, I., Bruce, S., Wagner, R., & Tyring, S. K. (1996). Prevalence of HHV-8 in cutaneous neoplasms. Journal of Investigative Medicine, 44(1), 52A.