Prevalence of HHV-8 in cutaneous neoplasms

Angela Yen, Peter Rady, Allison Jones, Ida Orengo, Suzanne Bruce, Richard Wagner, Stephen K. Tyring

Research output: Contribution to journalArticle

Abstract

Recently, Human Herpes Virus 8 (HHV-8) has been proposed to be the putative virus in the development of Kaposi's sarcoma in AIDS patients (AIDS-KS). To identify the presence and prevalence of HHV-8 in lesions other than in AIDS-KS, PCR analysis for HHV-8 DNA sequences was performed on 13 samples of AIDS-KS, 18 samples of classic Kaposi's sarcoma (non-KS) proliferative skin lesions (basal cell carcinomas, squamous cell carcinomas, actinic keratoses, verruca vulgaris, atypical squamous proliferations, and seborrheic keratoses) from immunosuppressed organ transplant patients, and 7 samples of primary and 5 samples of recurrent basal cell (BCC) and squamous cell carcinomas (SCC) from immuno-competent patients. HHV-88 was detected in 100% of the AIDS-KS samples, 72% of the CKS samples, 100% of the OKS samples, 82% of the non-KS samples from organ transplant patients, 14% of the primary BCC and SCC from immunocompetent patients, and 40% of the recurrent BCC and SCC from immunocompetent patients. These results suggest that the recently discovered HHV-8 is associated with lesions besides AIDS-KS, with the prevalence of HHV-8 being highest in AIDS-KS and OKS. In addition, the prevalence of HHV-8 in these samples is greater in recurrent carcinoma than in primary carcinoma. These data also suggest that HHV-8 may be involved, albeit not solely responsible, in the pathogenesis of KS and carcinomas.

Original languageEnglish (US)
JournalJournal of Investigative Medicine
Volume44
Issue number1
StatePublished - 1996
Externally publishedYes

Fingerprint

Skin Neoplasms
Viruses
Acquired Immunodeficiency Syndrome
Squamous Cell Carcinoma
Transplants
Kaposi's Sarcoma
Carcinoma
Seborrheic Keratosis
Actinic Keratosis
Warts
DNA sequences
Basal Cell Carcinoma
Skin
Cells
Polymerase Chain Reaction
Epithelial Cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Yen, A., Rady, P., Jones, A., Orengo, I., Bruce, S., Wagner, R., & Tyring, S. K. (1996). Prevalence of HHV-8 in cutaneous neoplasms. Journal of Investigative Medicine, 44(1).

Prevalence of HHV-8 in cutaneous neoplasms. / Yen, Angela; Rady, Peter; Jones, Allison; Orengo, Ida; Bruce, Suzanne; Wagner, Richard; Tyring, Stephen K.

In: Journal of Investigative Medicine, Vol. 44, No. 1, 1996.

Research output: Contribution to journalArticle

Yen, A, Rady, P, Jones, A, Orengo, I, Bruce, S, Wagner, R & Tyring, SK 1996, 'Prevalence of HHV-8 in cutaneous neoplasms', Journal of Investigative Medicine, vol. 44, no. 1.
Yen A, Rady P, Jones A, Orengo I, Bruce S, Wagner R et al. Prevalence of HHV-8 in cutaneous neoplasms. Journal of Investigative Medicine. 1996;44(1).
Yen, Angela ; Rady, Peter ; Jones, Allison ; Orengo, Ida ; Bruce, Suzanne ; Wagner, Richard ; Tyring, Stephen K. / Prevalence of HHV-8 in cutaneous neoplasms. In: Journal of Investigative Medicine. 1996 ; Vol. 44, No. 1.
@article{f71c27e046954a0fa0325c5e9d3cd731,
title = "Prevalence of HHV-8 in cutaneous neoplasms",
abstract = "Recently, Human Herpes Virus 8 (HHV-8) has been proposed to be the putative virus in the development of Kaposi's sarcoma in AIDS patients (AIDS-KS). To identify the presence and prevalence of HHV-8 in lesions other than in AIDS-KS, PCR analysis for HHV-8 DNA sequences was performed on 13 samples of AIDS-KS, 18 samples of classic Kaposi's sarcoma (non-KS) proliferative skin lesions (basal cell carcinomas, squamous cell carcinomas, actinic keratoses, verruca vulgaris, atypical squamous proliferations, and seborrheic keratoses) from immunosuppressed organ transplant patients, and 7 samples of primary and 5 samples of recurrent basal cell (BCC) and squamous cell carcinomas (SCC) from immuno-competent patients. HHV-88 was detected in 100{\%} of the AIDS-KS samples, 72{\%} of the CKS samples, 100{\%} of the OKS samples, 82{\%} of the non-KS samples from organ transplant patients, 14{\%} of the primary BCC and SCC from immunocompetent patients, and 40{\%} of the recurrent BCC and SCC from immunocompetent patients. These results suggest that the recently discovered HHV-8 is associated with lesions besides AIDS-KS, with the prevalence of HHV-8 being highest in AIDS-KS and OKS. In addition, the prevalence of HHV-8 in these samples is greater in recurrent carcinoma than in primary carcinoma. These data also suggest that HHV-8 may be involved, albeit not solely responsible, in the pathogenesis of KS and carcinomas.",
author = "Angela Yen and Peter Rady and Allison Jones and Ida Orengo and Suzanne Bruce and Richard Wagner and Tyring, {Stephen K.}",
year = "1996",
language = "English (US)",
volume = "44",
journal = "Journal of Investigative Medicine",
issn = "1081-5589",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Prevalence of HHV-8 in cutaneous neoplasms

AU - Yen, Angela

AU - Rady, Peter

AU - Jones, Allison

AU - Orengo, Ida

AU - Bruce, Suzanne

AU - Wagner, Richard

AU - Tyring, Stephen K.

PY - 1996

Y1 - 1996

N2 - Recently, Human Herpes Virus 8 (HHV-8) has been proposed to be the putative virus in the development of Kaposi's sarcoma in AIDS patients (AIDS-KS). To identify the presence and prevalence of HHV-8 in lesions other than in AIDS-KS, PCR analysis for HHV-8 DNA sequences was performed on 13 samples of AIDS-KS, 18 samples of classic Kaposi's sarcoma (non-KS) proliferative skin lesions (basal cell carcinomas, squamous cell carcinomas, actinic keratoses, verruca vulgaris, atypical squamous proliferations, and seborrheic keratoses) from immunosuppressed organ transplant patients, and 7 samples of primary and 5 samples of recurrent basal cell (BCC) and squamous cell carcinomas (SCC) from immuno-competent patients. HHV-88 was detected in 100% of the AIDS-KS samples, 72% of the CKS samples, 100% of the OKS samples, 82% of the non-KS samples from organ transplant patients, 14% of the primary BCC and SCC from immunocompetent patients, and 40% of the recurrent BCC and SCC from immunocompetent patients. These results suggest that the recently discovered HHV-8 is associated with lesions besides AIDS-KS, with the prevalence of HHV-8 being highest in AIDS-KS and OKS. In addition, the prevalence of HHV-8 in these samples is greater in recurrent carcinoma than in primary carcinoma. These data also suggest that HHV-8 may be involved, albeit not solely responsible, in the pathogenesis of KS and carcinomas.

AB - Recently, Human Herpes Virus 8 (HHV-8) has been proposed to be the putative virus in the development of Kaposi's sarcoma in AIDS patients (AIDS-KS). To identify the presence and prevalence of HHV-8 in lesions other than in AIDS-KS, PCR analysis for HHV-8 DNA sequences was performed on 13 samples of AIDS-KS, 18 samples of classic Kaposi's sarcoma (non-KS) proliferative skin lesions (basal cell carcinomas, squamous cell carcinomas, actinic keratoses, verruca vulgaris, atypical squamous proliferations, and seborrheic keratoses) from immunosuppressed organ transplant patients, and 7 samples of primary and 5 samples of recurrent basal cell (BCC) and squamous cell carcinomas (SCC) from immuno-competent patients. HHV-88 was detected in 100% of the AIDS-KS samples, 72% of the CKS samples, 100% of the OKS samples, 82% of the non-KS samples from organ transplant patients, 14% of the primary BCC and SCC from immunocompetent patients, and 40% of the recurrent BCC and SCC from immunocompetent patients. These results suggest that the recently discovered HHV-8 is associated with lesions besides AIDS-KS, with the prevalence of HHV-8 being highest in AIDS-KS and OKS. In addition, the prevalence of HHV-8 in these samples is greater in recurrent carcinoma than in primary carcinoma. These data also suggest that HHV-8 may be involved, albeit not solely responsible, in the pathogenesis of KS and carcinomas.

UR - http://www.scopus.com/inward/record.url?scp=33749572997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749572997&partnerID=8YFLogxK

M3 - Article

VL - 44

JO - Journal of Investigative Medicine

JF - Journal of Investigative Medicine

SN - 1081-5589

IS - 1

ER -