Prevalence of undifferentiated inflammatory arthropathy in patients with Hashimoto's thyroiditis in an endocrinology clinic

Luis M. Valderrama-Hinds, Eliangel García-Carrión, Evelyn Hernández, María I. Agostini, Omar R. Reyes-Morales, Liliana Fung, Soham Al Snih, Martin A. Rodríguez

    Research output: Contribution to journalArticle

    Abstract

    Aim: Rheumatic manifestations are common in patients with Hashimoto's thyroiditis (HT). Since previous reports on the prevalence of arthritis in this disease may have a rheumatology referral bias, we sought to establish the prevalence of undifferentiated inflammatory arthropathy (UIA) in unselected HT patients as seen in an endocrinology clinic. Methods: Cross-sectional study of 92 consecutive HT patients and no definite rheumatic disease from the Endocrinology Division, Hospital Universitario de Caracas diagnosed by the presence of anti-thyroid peroxidase antibodies (n = 68) or typical ultrasonographic findings (n = 24). Undifferentiated inflammatory arthropathy was defined as combination of morning stiffness and joint pain with ≥2 characteristics of inflammatory joint pain. The study was revised and approved by the Ethics Committee of our hospital and all patients signed an informed consent form. Results: Twenty-three patients (25%; 95% CI 16-34) met the criteria for UIA. Joints most commonly affected were the knees, hands and ankles and the most common pattern was oligoarticular (82.6%). In the multivariate analysis, variables associated to the presence of UIA were the presence of myalgia (odds ratio [OR] = 19.41; 95% CI = 2.38-158.38) and Raynaud's phenomenon (OR = 4.32; 95% CI = 1.01-18.60). No association was found with demographics, duration of disease, comorbidities or thyroid function status. Conclusions: Almost 1 in 4 patients with HT had no definite rheumatic disease present with UIA. An early identification of concurrent arthritis in HT patients is necessary for thorough differential diagnosis and prompt treatment initiation to halt potential joint damage and disability.

    Original languageEnglish (US)
    JournalInternational Journal of Rheumatic Diseases
    DOIs
    StateAccepted/In press - Jan 1 2019

    Fingerprint

    Hashimoto Disease
    Joint Diseases
    Endocrinology
    Arthralgia
    Rheumatic Diseases
    Arthritis
    Joints
    Clinical Ethics Committees
    Odds Ratio
    Consent Forms
    Iodide Peroxidase
    Raynaud Disease
    Myalgia
    Rheumatology
    Ankle
    Comorbidity
    Knee
    Thyroid Gland
    Differential Diagnosis
    Referral and Consultation

    Keywords

    • arthritis
    • autoimmune thyroiditis
    • Hashimoto's disease
    • prevalence
    • undifferentiated inflammatory arthropathy

    ASJC Scopus subject areas

    • Rheumatology

    Cite this

    Valderrama-Hinds, L. M., García-Carrión, E., Hernández, E., Agostini, M. I., Reyes-Morales, O. R., Fung, L., ... Rodríguez, M. A. (Accepted/In press). Prevalence of undifferentiated inflammatory arthropathy in patients with Hashimoto's thyroiditis in an endocrinology clinic. International Journal of Rheumatic Diseases. https://doi.org/10.1111/1756-185X.13722

    Prevalence of undifferentiated inflammatory arthropathy in patients with Hashimoto's thyroiditis in an endocrinology clinic. / Valderrama-Hinds, Luis M.; García-Carrión, Eliangel; Hernández, Evelyn; Agostini, María I.; Reyes-Morales, Omar R.; Fung, Liliana; Al Snih, Soham; Rodríguez, Martin A.

    In: International Journal of Rheumatic Diseases, 01.01.2019.

    Research output: Contribution to journalArticle

    Valderrama-Hinds, Luis M. ; García-Carrión, Eliangel ; Hernández, Evelyn ; Agostini, María I. ; Reyes-Morales, Omar R. ; Fung, Liliana ; Al Snih, Soham ; Rodríguez, Martin A. / Prevalence of undifferentiated inflammatory arthropathy in patients with Hashimoto's thyroiditis in an endocrinology clinic. In: International Journal of Rheumatic Diseases. 2019.
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    abstract = "Aim: Rheumatic manifestations are common in patients with Hashimoto's thyroiditis (HT). Since previous reports on the prevalence of arthritis in this disease may have a rheumatology referral bias, we sought to establish the prevalence of undifferentiated inflammatory arthropathy (UIA) in unselected HT patients as seen in an endocrinology clinic. Methods: Cross-sectional study of 92 consecutive HT patients and no definite rheumatic disease from the Endocrinology Division, Hospital Universitario de Caracas diagnosed by the presence of anti-thyroid peroxidase antibodies (n = 68) or typical ultrasonographic findings (n = 24). Undifferentiated inflammatory arthropathy was defined as combination of morning stiffness and joint pain with ≥2 characteristics of inflammatory joint pain. The study was revised and approved by the Ethics Committee of our hospital and all patients signed an informed consent form. Results: Twenty-three patients (25{\%}; 95{\%} CI 16-34) met the criteria for UIA. Joints most commonly affected were the knees, hands and ankles and the most common pattern was oligoarticular (82.6{\%}). In the multivariate analysis, variables associated to the presence of UIA were the presence of myalgia (odds ratio [OR] = 19.41; 95{\%} CI = 2.38-158.38) and Raynaud's phenomenon (OR = 4.32; 95{\%} CI = 1.01-18.60). No association was found with demographics, duration of disease, comorbidities or thyroid function status. Conclusions: Almost 1 in 4 patients with HT had no definite rheumatic disease present with UIA. An early identification of concurrent arthritis in HT patients is necessary for thorough differential diagnosis and prompt treatment initiation to halt potential joint damage and disability.",
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    author = "Valderrama-Hinds, {Luis M.} and Eliangel Garc{\'i}a-Carri{\'o}n and Evelyn Hern{\'a}ndez and Agostini, {Mar{\'i}a I.} and Reyes-Morales, {Omar R.} and Liliana Fung and {Al Snih}, Soham and Rodr{\'i}guez, {Martin A.}",
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    AU - Valderrama-Hinds, Luis M.

    AU - García-Carrión, Eliangel

    AU - Hernández, Evelyn

    AU - Agostini, María I.

    AU - Reyes-Morales, Omar R.

    AU - Fung, Liliana

    AU - Al Snih, Soham

    AU - Rodríguez, Martin A.

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    N2 - Aim: Rheumatic manifestations are common in patients with Hashimoto's thyroiditis (HT). Since previous reports on the prevalence of arthritis in this disease may have a rheumatology referral bias, we sought to establish the prevalence of undifferentiated inflammatory arthropathy (UIA) in unselected HT patients as seen in an endocrinology clinic. Methods: Cross-sectional study of 92 consecutive HT patients and no definite rheumatic disease from the Endocrinology Division, Hospital Universitario de Caracas diagnosed by the presence of anti-thyroid peroxidase antibodies (n = 68) or typical ultrasonographic findings (n = 24). Undifferentiated inflammatory arthropathy was defined as combination of morning stiffness and joint pain with ≥2 characteristics of inflammatory joint pain. The study was revised and approved by the Ethics Committee of our hospital and all patients signed an informed consent form. Results: Twenty-three patients (25%; 95% CI 16-34) met the criteria for UIA. Joints most commonly affected were the knees, hands and ankles and the most common pattern was oligoarticular (82.6%). In the multivariate analysis, variables associated to the presence of UIA were the presence of myalgia (odds ratio [OR] = 19.41; 95% CI = 2.38-158.38) and Raynaud's phenomenon (OR = 4.32; 95% CI = 1.01-18.60). No association was found with demographics, duration of disease, comorbidities or thyroid function status. Conclusions: Almost 1 in 4 patients with HT had no definite rheumatic disease present with UIA. An early identification of concurrent arthritis in HT patients is necessary for thorough differential diagnosis and prompt treatment initiation to halt potential joint damage and disability.

    AB - Aim: Rheumatic manifestations are common in patients with Hashimoto's thyroiditis (HT). Since previous reports on the prevalence of arthritis in this disease may have a rheumatology referral bias, we sought to establish the prevalence of undifferentiated inflammatory arthropathy (UIA) in unselected HT patients as seen in an endocrinology clinic. Methods: Cross-sectional study of 92 consecutive HT patients and no definite rheumatic disease from the Endocrinology Division, Hospital Universitario de Caracas diagnosed by the presence of anti-thyroid peroxidase antibodies (n = 68) or typical ultrasonographic findings (n = 24). Undifferentiated inflammatory arthropathy was defined as combination of morning stiffness and joint pain with ≥2 characteristics of inflammatory joint pain. The study was revised and approved by the Ethics Committee of our hospital and all patients signed an informed consent form. Results: Twenty-three patients (25%; 95% CI 16-34) met the criteria for UIA. Joints most commonly affected were the knees, hands and ankles and the most common pattern was oligoarticular (82.6%). In the multivariate analysis, variables associated to the presence of UIA were the presence of myalgia (odds ratio [OR] = 19.41; 95% CI = 2.38-158.38) and Raynaud's phenomenon (OR = 4.32; 95% CI = 1.01-18.60). No association was found with demographics, duration of disease, comorbidities or thyroid function status. Conclusions: Almost 1 in 4 patients with HT had no definite rheumatic disease present with UIA. An early identification of concurrent arthritis in HT patients is necessary for thorough differential diagnosis and prompt treatment initiation to halt potential joint damage and disability.

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    KW - autoimmune thyroiditis

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    KW - undifferentiated inflammatory arthropathy

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