TY - JOUR
T1 - Prevention of alterations in postoperative lymphocyte subpopulations by cimetidine and ibuprofen
AU - Hansbrough, John F.
AU - Zapata Sirvent, Ramon
AU - Bender, Edward M.
PY - 1986/1/1
Y1 - 1986/1/1
N2 - Surgical procedures probably result in a temporary state of immunosuppression. Identification of functional lymphocyte subclasses using appropriate monoclonal antibodies appears to serve as a sensitive, accurate, and reproducible measure of immune status in patients in many disease states. Using monoclonal antibodies specific for lymphocyte surface markers and immunofluorescent assay, we quantitated lymphocyte subpopulations in patients undergoing surgical procedures. Cholecystectomy, colon surgery, and coronary bypass procedures all resulted in postoperative decreases in helper and inducer populations and increases in cytotoxic suppressor populations, with resultant depressions in the helper to suppressor lymphocyte ratio. Studies in an additional group of patients who underwent cholecystectomy demonstrated that these changes could be prevented by perioperative administration of ibuprofen and cimetidine. These results suggest that prostaglandins and histamines are involved in immunoregulatory events after major operation. The ability of specific pharmacologic therapy to prevent alterations in lymphocyte populations suggests that postoperative immunity may be preserved, hopefully leading to greater host resistance against infection and tumor dissemination.
AB - Surgical procedures probably result in a temporary state of immunosuppression. Identification of functional lymphocyte subclasses using appropriate monoclonal antibodies appears to serve as a sensitive, accurate, and reproducible measure of immune status in patients in many disease states. Using monoclonal antibodies specific for lymphocyte surface markers and immunofluorescent assay, we quantitated lymphocyte subpopulations in patients undergoing surgical procedures. Cholecystectomy, colon surgery, and coronary bypass procedures all resulted in postoperative decreases in helper and inducer populations and increases in cytotoxic suppressor populations, with resultant depressions in the helper to suppressor lymphocyte ratio. Studies in an additional group of patients who underwent cholecystectomy demonstrated that these changes could be prevented by perioperative administration of ibuprofen and cimetidine. These results suggest that prostaglandins and histamines are involved in immunoregulatory events after major operation. The ability of specific pharmacologic therapy to prevent alterations in lymphocyte populations suggests that postoperative immunity may be preserved, hopefully leading to greater host resistance against infection and tumor dissemination.
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U2 - 10.1016/0002-9610(86)90080-2
DO - 10.1016/0002-9610(86)90080-2
M3 - Article
C2 - 3484914
AN - SCOPUS:0022618956
SN - 0002-9610
VL - 151
SP - 249
EP - 255
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 2
ER -