Prevention of alterations in postoperative lymphocyte subpopulations by cimetidine and ibuprofen

John F. Hansbrough, Ramon Zapata Sirvent, Edward M. Bender

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Surgical procedures probably result in a temporary state of immunosuppression. Identification of functional lymphocyte subclasses using appropriate monoclonal antibodies appears to serve as a sensitive, accurate, and reproducible measure of immune status in patients in many disease states. Using monoclonal antibodies specific for lymphocyte surface markers and immunofluorescent assay, we quantitated lymphocyte subpopulations in patients undergoing surgical procedures. Cholecystectomy, colon surgery, and coronary bypass procedures all resulted in postoperative decreases in helper and inducer populations and increases in cytotoxic suppressor populations, with resultant depressions in the helper to suppressor lymphocyte ratio. Studies in an additional group of patients who underwent cholecystectomy demonstrated that these changes could be prevented by perioperative administration of ibuprofen and cimetidine. These results suggest that prostaglandins and histamines are involved in immunoregulatory events after major operation. The ability of specific pharmacologic therapy to prevent alterations in lymphocyte populations suggests that postoperative immunity may be preserved, hopefully leading to greater host resistance against infection and tumor dissemination.

Original languageEnglish (US)
Pages (from-to)249-255
Number of pages7
JournalThe American Journal of Surgery
Volume151
Issue number2
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

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Ibuprofen
Cimetidine
Lymphocyte Subsets
Lymphocytes
Cholecystectomy
Monoclonal Antibodies
Population
Immunosuppression
Histamine
Prostaglandins
Immunity
Colon
Infection
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Surgery

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Prevention of alterations in postoperative lymphocyte subpopulations by cimetidine and ibuprofen. / Hansbrough, John F.; Zapata Sirvent, Ramon; Bender, Edward M.

In: The American Journal of Surgery, Vol. 151, No. 2, 01.01.1986, p. 249-255.

Research output: Contribution to journalArticle

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