Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked

Jie Yang, Xuesong Liu, Kapil Bhalla, Caryn Naekyung Kim, Ana Maria Ibrado, Jiyang Cai, Tsung I. Peng, Dean P. Jones, Xiaodong Wang

Research output: Contribution to journalArticle

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Abstract

Bcl-2 is an integral membrane protein located mainly on the outer membrane of mitochondria. Overexpression of Bcl-2 prevents cells from undergoing apoptosis in response to a variety of stimuli. Cytosolic cytochrome c is necessary for the initiation of the apoptotic program, suggesting a possible connection between Bcl-2 and cytochrome c, which is normally located in the mitochondrial intermembrane space. Cells undergoing apoptosis were found to have an elevation of cytochrome c in the cytosol and a corresponding decrease in the mitochondria. Overexpression of Bcl-2 prevented the efflux of cytochrome c from the mitochondria and the initiation of apoptosis. Thus, one possible role of Bcl-2 in prevention of apoptosis is to block cytochrome c release from mitochondria.

Original languageEnglish (US)
Pages (from-to)1129-1132
Number of pages4
JournalScience
Volume275
Issue number5303
DOIs
StatePublished - Feb 21 1997
Externally publishedYes

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Cytochromes c
Mitochondria
Apoptosis
Cytosol
Membrane Proteins
Membranes

ASJC Scopus subject areas

  • General

Cite this

Yang, J., Liu, X., Bhalla, K., Kim, C. N., Ibrado, A. M., Cai, J., ... Wang, X. (1997). Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science, 275(5303), 1129-1132. https://doi.org/10.1126/science.275.5303.1129

Prevention of apoptosis by Bcl-2 : Release of cytochrome c from mitochondria blocked. / Yang, Jie; Liu, Xuesong; Bhalla, Kapil; Kim, Caryn Naekyung; Ibrado, Ana Maria; Cai, Jiyang; Peng, Tsung I.; Jones, Dean P.; Wang, Xiaodong.

In: Science, Vol. 275, No. 5303, 21.02.1997, p. 1129-1132.

Research output: Contribution to journalArticle

Yang, J, Liu, X, Bhalla, K, Kim, CN, Ibrado, AM, Cai, J, Peng, TI, Jones, DP & Wang, X 1997, 'Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked', Science, vol. 275, no. 5303, pp. 1129-1132. https://doi.org/10.1126/science.275.5303.1129
Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J et al. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science. 1997 Feb 21;275(5303):1129-1132. https://doi.org/10.1126/science.275.5303.1129
Yang, Jie ; Liu, Xuesong ; Bhalla, Kapil ; Kim, Caryn Naekyung ; Ibrado, Ana Maria ; Cai, Jiyang ; Peng, Tsung I. ; Jones, Dean P. ; Wang, Xiaodong. / Prevention of apoptosis by Bcl-2 : Release of cytochrome c from mitochondria blocked. In: Science. 1997 ; Vol. 275, No. 5303. pp. 1129-1132.
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AU - Ibrado, Ana Maria

AU - Cai, Jiyang

AU - Peng, Tsung I.

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