Prevention of myocardial damage during cardiac operations

J. W. Kirklin, Vincent Conti, E. H. Blackstone

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

When the cardiopulmonary-bypass technic for cardiac operations began to evolve in the mid-1950's, there was wide enthusiasm for its potential benefits. It soon became apparent, however, that some operations resulted in early postoperative deaths and that most were due to some of acute cardiac failure, usually manifested by low cardiac output. These deaths, it was assumed, happened because the patients had serious heart disease. Only recently has it been realized that death from acute cardiac failure soon after cardiac operations is usually related to new, and often extensive, perioperative (during or within 24 hours of the procedure) myocardial necrosis and that necrosis has also been induced in many patients who survive. Even more recently, new technics of myocardial protection have reduced the occurrence and extent of perioperative myocardial necrosis. These technics promise to improve dramatically the early and late results of cardiac operations and also to allow more extensive and precise operating procedures.

Original languageEnglish (US)
Pages (from-to)135-141
Number of pages7
JournalNew England Journal of Medicine
Volume301
Issue number3
StatePublished - 1979
Externally publishedYes

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Necrosis
Heart Failure
Low Cardiac Output
Cardiopulmonary Bypass
Heart Diseases

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Prevention of myocardial damage during cardiac operations. / Kirklin, J. W.; Conti, Vincent; Blackstone, E. H.

In: New England Journal of Medicine, Vol. 301, No. 3, 1979, p. 135-141.

Research output: Contribution to journalArticle

Kirklin, JW, Conti, V & Blackstone, EH 1979, 'Prevention of myocardial damage during cardiac operations', New England Journal of Medicine, vol. 301, no. 3, pp. 135-141.
Kirklin, J. W. ; Conti, Vincent ; Blackstone, E. H. / Prevention of myocardial damage during cardiac operations. In: New England Journal of Medicine. 1979 ; Vol. 301, No. 3. pp. 135-141.
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