Prevention of rift valley fever in rhesus monkeys with interferon-a

John C. Morrill, Gerald B. Jennings, Thomas M. Cosgriff, Paul H. Gibbs, C. J. Peters

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Abstract

Prophylactic and therapeutic efficacy of recombinant leukocyte A interferon (rIFN-aA) and Sendai virus-induced human leukocyte interferon (HuIFN-a) administered intramuscularly to Rift Valley fever virus (RVFV)-infected rhesus monkeys was studied. Clinical, virologic, immunologic, and hemostatic parameters were monitored. Five daily inoculations of 5 x 10s units of either interferon product per kilogram of body weight, initiated 24 hours before or 6 hours after RVFV infection, prevented or greatly suppressed viremia. No clinical signs of disease or laboratory evidence of impaired hemostasis was observed. Serum neutralizing antibody to RVFV was detected within 6 days of virus inoculation. Prophylactic administration of 5 x 104 or 5 x 103 units of rIFN-aA per kilogram also limited viremia, hepatocellular damage, and hemostatic derangement. Untreated, RVFV- infected, control monkeys developed high-titered viremia, clinical disease, and impaired hemostasis. These data suggest that rIFN-aA and HuIFN-a are effective in protecting RVFV-infected rhesus monkeys from viremia and hepatocellular damage and may be beneficial in human RVF infection.

Original languageEnglish (US)
Pages (from-to)S815-S825
JournalReviews of infectious diseases
Volume11
DOIs
StatePublished - May 1989

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ASJC Scopus subject areas

  • Microbiology (medical)

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Morrill, J. C., Jennings, G. B., Cosgriff, T. M., Gibbs, P. H., & Peters, C. J. (1989). Prevention of rift valley fever in rhesus monkeys with interferon-a. Reviews of infectious diseases, 11, S815-S825. https://doi.org/10.1093/clinids/11.Supplement_4.S815