Prevention of sugar-induced cataractogenesis in rats by butylated hydroxytoluene

S. K. Srivastava, N. H. Ansari

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

Senile cataractogenesis advanced by diabetes, thought mainly to be due to accumulation of polyols, is one of the major causes of blindness throughout the world. Rats fed a 50% galactose diet developed mature cataracts in 23 days, whereas rats fed a 50% galactose diet with 0.4% butylated hydroxytoluene (BHT) had clear lenses. On day 10, both groups had comparable galactitol levels in the lens, but hydration in the former group, as determined by the lens weight, was ~10% more than in the latter. On day 23, galactitol levels in the latter group were 92% higher (~85 mM) than in the former group, but lens weight was lower. These results indicate that sugar-induced cataractogenesis in rats is not solely due to polyol accumulation. Oxidative damage is probably a major cause of the advancement of cataractogenesis.

Original languageEnglish (US)
Pages (from-to)1505-1508
Number of pages4
JournalDiabetes
Volume37
Issue number11
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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