Prevention of the hemorrhagic hypotension-induced hepatic arterial vasoconstriction by L-arginine and naloxone

Zoltán Benyó, Csaba Szabo, Arisztid G B Kovách, Péter Sándor

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The possible involvement of the L-arginine-nitric oxide pathway and endogenous opioid mechanisms in the hemorrhagic hypotension-(HH) induced changes of hepatic arterial blood flow and vascular resistance was studied in cats. During HH hepatic arterial blood flow was significantly higher both in L-arginine-and naloxone-treated animals than in controls. Furthermore, HH induced a significant increase of the hepatic vascular resistance in the control group, which was prevented by L-arginine or naloxone treatment. Because inhibition of the nitric oxide synthesis by NG-nitro-L-arginine in normotensive cats induced a similar increase of the hepatic vascular resistance to that observed during HH in the control group, our results indicate that impairment of the endothelial function may be responsible for the hemorrhage-induced L-arginine-and naloxone-reversible hepatic arterial vasoconstriction. This hypothesis is consistent with our previous observations demonstrating the development of endothelial dysfunction in the feline hepatic artery during HH.

Original languageEnglish (US)
Pages (from-to)342-346
Number of pages5
JournalShock
Volume11
Issue number5
StatePublished - May 1999
Externally publishedYes

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Controlled Hypotension
Naloxone
Vasoconstriction
Arginine
Vascular Resistance
Liver
Nitric Oxide
Cats
Control Groups
Nitroarginine
Hepatic Artery
Felidae
Opioid Analgesics
Hemorrhage

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Physiology

Cite this

Prevention of the hemorrhagic hypotension-induced hepatic arterial vasoconstriction by L-arginine and naloxone. / Benyó, Zoltán; Szabo, Csaba; Kovách, Arisztid G B; Sándor, Péter.

In: Shock, Vol. 11, No. 5, 05.1999, p. 342-346.

Research output: Contribution to journalArticle

Benyó, Zoltán ; Szabo, Csaba ; Kovách, Arisztid G B ; Sándor, Péter. / Prevention of the hemorrhagic hypotension-induced hepatic arterial vasoconstriction by L-arginine and naloxone. In: Shock. 1999 ; Vol. 11, No. 5. pp. 342-346.
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