Primary amyloidosis-induced nail dystrophy

William Tausend, Megan Neill, Brent Kelly

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Primary amyloidosis is caused by a monoclonal proliferation of plasma cells and is capable of producing cutaneous lesions. A 56- year-old male was admitted to the hospital for evaluation of chronic back pain and acute lower extremity weakness. On examination, he was noted to have subungual verrucous plaques with overlying nail dystrophy on his bilateral thumbs. A biopsy of one subungual lesion showed a deposition of amorphous material in the dermis that stained with Congo red and crystal violet. These cutaneous lesions ultimately led to the diagnosis of plasma cell dyscrasia and primary amyloidosis. Based on the literature search, primary amyloidosis presenting with this degree of subungual thickening and overlying nail dystrophy has not been previously reported.

Original languageEnglish (US)
JournalDermatology Online Journal
Volume20
Issue number1
StatePublished - 2014

Fingerprint

Nails
Gentian Violet
Congo Red
Skin
Paraproteinemias
Thumb
Back Pain
Dermis
Plasma Cells
Chronic Pain
Lower Extremity
Biopsy
Primary amyloidosis

Keywords

  • Nail dystrophy
  • Plasma cell dyscrasia
  • Primary amyloidosis

ASJC Scopus subject areas

  • Dermatology

Cite this

Primary amyloidosis-induced nail dystrophy. / Tausend, William; Neill, Megan; Kelly, Brent.

In: Dermatology Online Journal, Vol. 20, No. 1, 2014.

Research output: Contribution to journalArticle

Tausend, William ; Neill, Megan ; Kelly, Brent. / Primary amyloidosis-induced nail dystrophy. In: Dermatology Online Journal. 2014 ; Vol. 20, No. 1.
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