Primary biliary cirrhosis has high wait-list mortality among patients listed for liver transplantation

Ashwani K. Singal, Xiao Fang, Mohamed Kaif, Mohsen Hasanin, Brendan M. Mcguire, Yong Fang Kuo, Russell H. Wiesner

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Patients with primary sclerosing cholangitis (PSC) have frequent episodes of cholangitis with potential for high mortality while waiting for liver transplantation. However, data on wait-list mortality specific to liver disease etiology are limited. Using United Network for Organ Sharing (UNOS) database (2002–2013), of 81 592 listed patients, 11 284 (13.8%) died while waiting for transplant. Primary biliary cirrhosis (PBC) patients (N = 3491) compared to PSC (N = 4905) differed with age (56 vs. 47 years), female gender (88% vs. 33%), black race (6% vs. 13%), and BMI (25 vs. 27), P < 0.0001 for all. A total of 993 (11.8%) patients died while waiting for the transplant list. Using competing risk analysis controlling for baseline recipient factors and accounting for receipt of liver transplantation (LT), PBC compared to patients with PSC had higher overall and 3-month wait-list mortality (21.6% vs. 12.7% and 5.0% vs. 2.9%, respectively, Gray's test P < 0.001), [1.25 (1.07–1.47)]. Repeat analysis including all etiologies showed higher wait-list mortality for PBC compared to most etiologies, except for patients listed for diagnosis of alcoholic liver disease (ALD) + hepatitis C virus (HCV). Patients with PBC have high mortality while waiting for liver transplantation. These novel findings suggest that patients with PBC listed for LT may be considered for model for end-stage disease (MELD) exception points.

Original languageEnglish (US)
Pages (from-to)454-462
Number of pages9
JournalTransplant International
Volume30
Issue number5
DOIs
StatePublished - May 2017

Keywords

  • cirrhosis
  • transplantation
  • wait-list mortality

ASJC Scopus subject areas

  • Transplantation

Fingerprint Dive into the research topics of 'Primary biliary cirrhosis has high wait-list mortality among patients listed for liver transplantation'. Together they form a unique fingerprint.

  • Cite this