Primary pneumonic plague in the African Green monkey as a model for treatment efficacy evaluation

R. Colby Layton, Trevor Brasel, Andrew Gigliotti, Edward Barr, Steven Storch, Leslie Myers, Charles Hobbs, Frederick Koster

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background Primary pneumonic plague is rare among humans, but treatment efficacy may be tested in appropriate animal models under the FDA 'Animal Rule'.Methods Ten African Green monkeys (AGMs) inhaled 44-255 LD50 doses of aerosolized Yersinia pestis strain CO92. Continuous telemetry, arterial blood gases, chest radiography, blood culture, and clinical pathology monitored disease progression.Results Onset of fever, >39°C detected by continuous telemetry, 52-80 hours post-exposure was the first sign of systemic disease and provides a distinct signal for treatment initiation. Secondary endpoints of disease severity include tachypnea measured by telemetry, bacteremia, extent of pneumonia imaged by chest x-ray, and serum lactate dehydrogenase enzyme levels.Conclusions Inhaled Y. pestis in the AGM results in a rapidly progressive and uniformly fatal disease with fever and multifocal pneumonia, serving as a rigorous test model for antibiotic efficacy studies.

Original languageEnglish (US)
Pages (from-to)6-17
Number of pages12
JournalJournal of Medical Primatology
Volume40
Issue number1
DOIs
StatePublished - Feb 2011
Externally publishedYes

Fingerprint

Cercopithecus aethiops
Telemetry
Plague
plague
telemetry
Yersinia pestis
lungs
chest
pneumonia
fever
Pneumonia
Fever
Thorax
Tachypnea
bacteremia
Clinical Pathology
Lethal Dose 50
blood gases
Bacteremia
blood serum

Keywords

  • African green monkey
  • Plague
  • Pneumonia
  • Telemetry

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Primary pneumonic plague in the African Green monkey as a model for treatment efficacy evaluation. / Layton, R. Colby; Brasel, Trevor; Gigliotti, Andrew; Barr, Edward; Storch, Steven; Myers, Leslie; Hobbs, Charles; Koster, Frederick.

In: Journal of Medical Primatology, Vol. 40, No. 1, 02.2011, p. 6-17.

Research output: Contribution to journalArticle

Layton, RC, Brasel, T, Gigliotti, A, Barr, E, Storch, S, Myers, L, Hobbs, C & Koster, F 2011, 'Primary pneumonic plague in the African Green monkey as a model for treatment efficacy evaluation', Journal of Medical Primatology, vol. 40, no. 1, pp. 6-17. https://doi.org/10.1111/j.1600-0684.2010.00443.x
Layton, R. Colby ; Brasel, Trevor ; Gigliotti, Andrew ; Barr, Edward ; Storch, Steven ; Myers, Leslie ; Hobbs, Charles ; Koster, Frederick. / Primary pneumonic plague in the African Green monkey as a model for treatment efficacy evaluation. In: Journal of Medical Primatology. 2011 ; Vol. 40, No. 1. pp. 6-17.
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