Abstract
Background Mesenchymal malignancies of salivary origin are rare and are histologically diverse. We reviewed our experience with these tumors, as well as the published literature, with an emphasis on treatment modalities and prognosis. Methods We identified 17 patients treated for malignant mesenchymal cell tumors at The University of Texas MD Anderson Cancer Center between 1990 and 2007. We compared our results to the literature from January 1990 to July 2010. Results Tumors were located primarily in the parotid gland and were primarily T1 tumors (<5 cm). All patients were treated with surgical resection, and 13 patients were given adjuvant therapy. Seven patients (41%) had recurrence, and 4 developed distant metastases. The overall 5-year and 10-year survival rates were 42% and 20%, respectively. Conclusions Our case series and literature review show that sarcomas of the salivary glands have a high rate of recurrence and are associated with a poor prognosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1551-1557 |
| Number of pages | 7 |
| Journal | Head and Neck |
| Volume | 35 |
| Issue number | 11 |
| DOIs | |
| State | Published - Jun 5 2013 |
| Externally published | Yes |
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Keywords
- mesenchymal
- parotid
- salivary gland
- sarcoma
- surgery
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Primary sarcomas of the salivary glands : Case series and literature review. / Cockerill, Cara C.; Daram, Shiva; El-Naggar, Adel K.; Hanna, Ehab Y.; Weber, Randal S.; Kupferman, Michael E.
In: Head and Neck, Vol. 35, No. 11, 05.06.2013, p. 1551-1557.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Primary sarcomas of the salivary glands
T2 - Case series and literature review
AU - Cockerill, Cara C.
AU - Daram, Shiva
AU - El-Naggar, Adel K.
AU - Hanna, Ehab Y.
AU - Weber, Randal S.
AU - Kupferman, Michael E.
PY - 2013/6/5
Y1 - 2013/6/5
N2 - Background Mesenchymal malignancies of salivary origin are rare and are histologically diverse. We reviewed our experience with these tumors, as well as the published literature, with an emphasis on treatment modalities and prognosis. Methods We identified 17 patients treated for malignant mesenchymal cell tumors at The University of Texas MD Anderson Cancer Center between 1990 and 2007. We compared our results to the literature from January 1990 to July 2010. Results Tumors were located primarily in the parotid gland and were primarily T1 tumors (<5 cm). All patients were treated with surgical resection, and 13 patients were given adjuvant therapy. Seven patients (41%) had recurrence, and 4 developed distant metastases. The overall 5-year and 10-year survival rates were 42% and 20%, respectively. Conclusions Our case series and literature review show that sarcomas of the salivary glands have a high rate of recurrence and are associated with a poor prognosis.
AB - Background Mesenchymal malignancies of salivary origin are rare and are histologically diverse. We reviewed our experience with these tumors, as well as the published literature, with an emphasis on treatment modalities and prognosis. Methods We identified 17 patients treated for malignant mesenchymal cell tumors at The University of Texas MD Anderson Cancer Center between 1990 and 2007. We compared our results to the literature from January 1990 to July 2010. Results Tumors were located primarily in the parotid gland and were primarily T1 tumors (<5 cm). All patients were treated with surgical resection, and 13 patients were given adjuvant therapy. Seven patients (41%) had recurrence, and 4 developed distant metastases. The overall 5-year and 10-year survival rates were 42% and 20%, respectively. Conclusions Our case series and literature review show that sarcomas of the salivary glands have a high rate of recurrence and are associated with a poor prognosis.
KW - mesenchymal
KW - parotid
KW - salivary gland
KW - sarcoma
KW - surgery
UR - http://www.scopus.com/inward/record.url?scp=84886391479&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886391479&partnerID=8YFLogxK
U2 - 10.1002/hed.23203
DO - 10.1002/hed.23203
M3 - Article
C2 - 23728801
AN - SCOPUS:84886391479
VL - 35
SP - 1551
EP - 1557
JO - Head and Neck Surgery
JF - Head and Neck Surgery
SN - 1043-3074
IS - 11
ER -