Primary structure of cholera toxin β-chain

A glycoprotein hormone analog?

Alexander Kurosky, Daiel E. Markel, Johnny Peterson, Walter M. Fitch

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The completed sequence of the β-chain of cholera toxin (103 amino acid residues) was compared to the β-chains of chorionic gonadotropin, thyrotropin, luteinizing, and follicle stimulating hormones. The overall chemical similarity of the toxin β-chain to the hormones was not statistically different from random; however, a comparison of the first 40 residues of the toxin β-chain to the glycoprotein hormones revealed a segment of the hormones which was significantly chemically similar. The probability was <.003 that the similarity was due to chance.

Original languageEnglish (US)
Pages (from-to)299-301
Number of pages3
JournalScience
Volume195
Issue number4275
StatePublished - 1977

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Cholera Toxin
Glycoproteins
Hormones
Follicle Stimulating Hormone
Thyrotropin
Chorionic Gonadotropin
Amino Acids

ASJC Scopus subject areas

  • General

Cite this

Kurosky, A., Markel, D. E., Peterson, J., & Fitch, W. M. (1977). Primary structure of cholera toxin β-chain: A glycoprotein hormone analog? Science, 195(4275), 299-301.

Primary structure of cholera toxin β-chain : A glycoprotein hormone analog? / Kurosky, Alexander; Markel, Daiel E.; Peterson, Johnny; Fitch, Walter M.

In: Science, Vol. 195, No. 4275, 1977, p. 299-301.

Research output: Contribution to journalArticle

Kurosky, A, Markel, DE, Peterson, J & Fitch, WM 1977, 'Primary structure of cholera toxin β-chain: A glycoprotein hormone analog?', Science, vol. 195, no. 4275, pp. 299-301.
Kurosky, Alexander ; Markel, Daiel E. ; Peterson, Johnny ; Fitch, Walter M. / Primary structure of cholera toxin β-chain : A glycoprotein hormone analog?. In: Science. 1977 ; Vol. 195, No. 4275. pp. 299-301.
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