Primary structure of cholera toxin β-chain: A glycoprotein hormone analog?

Alexander Kurosky; Daiel E. Markel; Johnny W. Peterson; Walter M. Fitch

doi:10.1126/science.831277

Primary structure of cholera toxin β-chain: A glycoprotein hormone analog?

Alexander Kurosky, Daiel E. Markel, Johnny W. Peterson, Walter M. Fitch

Microbiology And Immunology

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Abstract

The completed sequence of the β-chain of cholera toxin (103 amino acid residues) was compared to the β-chains of chorionic gonadotropin, thyrotropin, luteinizing, and follicle stimulating hormones. The overall chemical similarity of the toxin β-chain to the hormones was not statistically different from random; however, a comparison of the first 40 residues of the toxin β-chain to the glycoprotein hormones revealed a segment of the hormones which was significantly chemically similar. The probability was <.003 that the similarity was due to chance.

Original language	English (US)
Pages (from-to)	299-301
Number of pages	3
Journal	Science
Volume	195
Issue number	4275
DOIs	https://doi.org/10.1126/science.831277
State	Published - 1977

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title = "Primary structure of cholera toxin β-chain: A glycoprotein hormone analog?",

abstract = "The completed sequence of the β-chain of cholera toxin (103 amino acid residues) was compared to the β-chains of chorionic gonadotropin, thyrotropin, luteinizing, and follicle stimulating hormones. The overall chemical similarity of the toxin β-chain to the hormones was not statistically different from random; however, a comparison of the first 40 residues of the toxin β-chain to the glycoprotein hormones revealed a segment of the hormones which was significantly chemically similar. The probability was <.003 that the similarity was due to chance.",

author = "Alexander Kurosky and Markel, {Daiel E.} and Peterson, {Johnny W.} and Fitch, {Walter M.}",

year = "1977",

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T2 - A glycoprotein hormone analog?

AU - Kurosky, Alexander

AU - Markel, Daiel E.

AU - Peterson, Johnny W.

AU - Fitch, Walter M.

PY - 1977

Y1 - 1977

N2 - The completed sequence of the β-chain of cholera toxin (103 amino acid residues) was compared to the β-chains of chorionic gonadotropin, thyrotropin, luteinizing, and follicle stimulating hormones. The overall chemical similarity of the toxin β-chain to the hormones was not statistically different from random; however, a comparison of the first 40 residues of the toxin β-chain to the glycoprotein hormones revealed a segment of the hormones which was significantly chemically similar. The probability was <.003 that the similarity was due to chance.

AB - The completed sequence of the β-chain of cholera toxin (103 amino acid residues) was compared to the β-chains of chorionic gonadotropin, thyrotropin, luteinizing, and follicle stimulating hormones. The overall chemical similarity of the toxin β-chain to the hormones was not statistically different from random; however, a comparison of the first 40 residues of the toxin β-chain to the glycoprotein hormones revealed a segment of the hormones which was significantly chemically similar. The probability was <.003 that the similarity was due to chance.

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SP - 299

EP - 301

JO - Science

JF - Science

IS - 4275

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Primary structure of cholera toxin β-chain: A glycoprotein hormone analog?

Abstract

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