Primary structure of cholera toxin β-chain: A glycoprotein hormone analog?

Alexander Kurosky, Daiel E. Markel, Johnny W. Peterson, Walter M. Fitch

Research output: Contribution to journalArticle

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Abstract

The completed sequence of the β-chain of cholera toxin (103 amino acid residues) was compared to the β-chains of chorionic gonadotropin, thyrotropin, luteinizing, and follicle stimulating hormones. The overall chemical similarity of the toxin β-chain to the hormones was not statistically different from random; however, a comparison of the first 40 residues of the toxin β-chain to the glycoprotein hormones revealed a segment of the hormones which was significantly chemically similar. The probability was <.003 that the similarity was due to chance.

Original languageEnglish (US)
Pages (from-to)299-301
Number of pages3
JournalScience
Volume195
Issue number4275
DOIs
StatePublished - Jan 1 1977

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