The oncogenesis of primary transitional cell carcinoma appears similar to that of transitional cell carcinoma elsewhere in the urinary tract. Symptoms and physical findings in 26 patients with primary transitional cell carcinoma of the prostate were not unlike those noticed by patients with adenocarcinoma of the prostate. Osseous metastasis was commonly osteolytic. The neoplasms were usually extensive and poorly differentiated when first discovered and 25% were associated with a coexisting adenocarcinoma. These neoplasms were not hormonally dependent and hormonal manipulation did not appear effective. Similarly, response to radiation therapy was not impressive. Surgical excision of the lesion, if feasible, appeared advisable. The prognosis for patients with this malignancy is poor.
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