Pro- and anti-inflammatory balance of septic patients is associated with severity and outcome

Alberto Dougnac, Ricardo Castro, Arnoldo Riquelme, Mario Calvo, Eliseo Eugenin, Marco Arellano, Alejandro Pattillo, Tomas Regueira, Marcelo Mercado, Max Andresen

Research output: Contribution to journalArticle

Abstract

Purpose: To study inflammatory profile in patients with sepsis, severe sepsis and septic shock with regards to organ dysfunction and outcome, and to identify a pattern associated with more catastrophic course of illness, organ failure and risk of death. Material and methods: Twenty-nine consecutive patients with sepsis admitted to a medical Intensive Care Unit of a tertiary university hospital (November 2002-December 2003). Plasmatic levels of interleukin-6 (IL-6) and interleukin-10 (IL-10) as pro-inflammatory and anti-inflammatory markers were measured at baseline, 12, 24 and 48 hours of evolution. Results: There is a positive association between higher levels of IL-6 and severity of the septic process, organ dysfunctions and risk of death, statistically significant at anytime (at baseline, 12, 24 and 48 hours, p <0.05). Higher IL-6/IL-10 ratios associate significantly with risk of death at 24 hours (RR=1.45 if higher or equal to the median). Conclusions: Plasmatic biomarkers measurement during the initial phase of sepsis may help to individualize therapy. An evaluation at 24 h based on IL-6/IL-10 ratio may anticipate a more aggressive inflammatory profile. These patients would specially benefit from immunomodulating therapies to improve survival.

Original languageEnglish (US)
Pages (from-to)99-107
Number of pages9
JournalCritical Care and Shock
Volume10
Issue number3
StatePublished - Aug 1 2007
Externally publishedYes

Fingerprint

Interleukin-6
Sepsis
Anti-Inflammatory Agents
Interleukin-10
Catastrophic Illness
Septic Shock
Tertiary Care Centers
Intensive Care Units
Biomarkers
Survival
Therapeutics

Keywords

  • Inflammation
  • Interleukin
  • Outcome
  • Sepsis
  • Severity

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Dougnac, A., Castro, R., Riquelme, A., Calvo, M., Eugenin, E., Arellano, M., ... Andresen, M. (2007). Pro- and anti-inflammatory balance of septic patients is associated with severity and outcome. Critical Care and Shock, 10(3), 99-107.

Pro- and anti-inflammatory balance of septic patients is associated with severity and outcome. / Dougnac, Alberto; Castro, Ricardo; Riquelme, Arnoldo; Calvo, Mario; Eugenin, Eliseo; Arellano, Marco; Pattillo, Alejandro; Regueira, Tomas; Mercado, Marcelo; Andresen, Max.

In: Critical Care and Shock, Vol. 10, No. 3, 01.08.2007, p. 99-107.

Research output: Contribution to journalArticle

Dougnac, A, Castro, R, Riquelme, A, Calvo, M, Eugenin, E, Arellano, M, Pattillo, A, Regueira, T, Mercado, M & Andresen, M 2007, 'Pro- and anti-inflammatory balance of septic patients is associated with severity and outcome', Critical Care and Shock, vol. 10, no. 3, pp. 99-107.
Dougnac A, Castro R, Riquelme A, Calvo M, Eugenin E, Arellano M et al. Pro- and anti-inflammatory balance of septic patients is associated with severity and outcome. Critical Care and Shock. 2007 Aug 1;10(3):99-107.
Dougnac, Alberto ; Castro, Ricardo ; Riquelme, Arnoldo ; Calvo, Mario ; Eugenin, Eliseo ; Arellano, Marco ; Pattillo, Alejandro ; Regueira, Tomas ; Mercado, Marcelo ; Andresen, Max. / Pro- and anti-inflammatory balance of septic patients is associated with severity and outcome. In: Critical Care and Shock. 2007 ; Vol. 10, No. 3. pp. 99-107.
@article{2248432f004b481ba1ed8e910ab0e19d,
title = "Pro- and anti-inflammatory balance of septic patients is associated with severity and outcome",
abstract = "Purpose: To study inflammatory profile in patients with sepsis, severe sepsis and septic shock with regards to organ dysfunction and outcome, and to identify a pattern associated with more catastrophic course of illness, organ failure and risk of death. Material and methods: Twenty-nine consecutive patients with sepsis admitted to a medical Intensive Care Unit of a tertiary university hospital (November 2002-December 2003). Plasmatic levels of interleukin-6 (IL-6) and interleukin-10 (IL-10) as pro-inflammatory and anti-inflammatory markers were measured at baseline, 12, 24 and 48 hours of evolution. Results: There is a positive association between higher levels of IL-6 and severity of the septic process, organ dysfunctions and risk of death, statistically significant at anytime (at baseline, 12, 24 and 48 hours, p <0.05). Higher IL-6/IL-10 ratios associate significantly with risk of death at 24 hours (RR=1.45 if higher or equal to the median). Conclusions: Plasmatic biomarkers measurement during the initial phase of sepsis may help to individualize therapy. An evaluation at 24 h based on IL-6/IL-10 ratio may anticipate a more aggressive inflammatory profile. These patients would specially benefit from immunomodulating therapies to improve survival.",
keywords = "Inflammation, Interleukin, Outcome, Sepsis, Severity",
author = "Alberto Dougnac and Ricardo Castro and Arnoldo Riquelme and Mario Calvo and Eliseo Eugenin and Marco Arellano and Alejandro Pattillo and Tomas Regueira and Marcelo Mercado and Max Andresen",
year = "2007",
month = "8",
day = "1",
language = "English (US)",
volume = "10",
pages = "99--107",
journal = "Critical Care and Shock",
issn = "1410-7767",
publisher = "Indonesian Society of Critical Care Medicine",
number = "3",

}

TY - JOUR

T1 - Pro- and anti-inflammatory balance of septic patients is associated with severity and outcome

AU - Dougnac, Alberto

AU - Castro, Ricardo

AU - Riquelme, Arnoldo

AU - Calvo, Mario

AU - Eugenin, Eliseo

AU - Arellano, Marco

AU - Pattillo, Alejandro

AU - Regueira, Tomas

AU - Mercado, Marcelo

AU - Andresen, Max

PY - 2007/8/1

Y1 - 2007/8/1

N2 - Purpose: To study inflammatory profile in patients with sepsis, severe sepsis and septic shock with regards to organ dysfunction and outcome, and to identify a pattern associated with more catastrophic course of illness, organ failure and risk of death. Material and methods: Twenty-nine consecutive patients with sepsis admitted to a medical Intensive Care Unit of a tertiary university hospital (November 2002-December 2003). Plasmatic levels of interleukin-6 (IL-6) and interleukin-10 (IL-10) as pro-inflammatory and anti-inflammatory markers were measured at baseline, 12, 24 and 48 hours of evolution. Results: There is a positive association between higher levels of IL-6 and severity of the septic process, organ dysfunctions and risk of death, statistically significant at anytime (at baseline, 12, 24 and 48 hours, p <0.05). Higher IL-6/IL-10 ratios associate significantly with risk of death at 24 hours (RR=1.45 if higher or equal to the median). Conclusions: Plasmatic biomarkers measurement during the initial phase of sepsis may help to individualize therapy. An evaluation at 24 h based on IL-6/IL-10 ratio may anticipate a more aggressive inflammatory profile. These patients would specially benefit from immunomodulating therapies to improve survival.

AB - Purpose: To study inflammatory profile in patients with sepsis, severe sepsis and septic shock with regards to organ dysfunction and outcome, and to identify a pattern associated with more catastrophic course of illness, organ failure and risk of death. Material and methods: Twenty-nine consecutive patients with sepsis admitted to a medical Intensive Care Unit of a tertiary university hospital (November 2002-December 2003). Plasmatic levels of interleukin-6 (IL-6) and interleukin-10 (IL-10) as pro-inflammatory and anti-inflammatory markers were measured at baseline, 12, 24 and 48 hours of evolution. Results: There is a positive association between higher levels of IL-6 and severity of the septic process, organ dysfunctions and risk of death, statistically significant at anytime (at baseline, 12, 24 and 48 hours, p <0.05). Higher IL-6/IL-10 ratios associate significantly with risk of death at 24 hours (RR=1.45 if higher or equal to the median). Conclusions: Plasmatic biomarkers measurement during the initial phase of sepsis may help to individualize therapy. An evaluation at 24 h based on IL-6/IL-10 ratio may anticipate a more aggressive inflammatory profile. These patients would specially benefit from immunomodulating therapies to improve survival.

KW - Inflammation

KW - Interleukin

KW - Outcome

KW - Sepsis

KW - Severity

UR - http://www.scopus.com/inward/record.url?scp=34547662425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547662425&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 99

EP - 107

JO - Critical Care and Shock

JF - Critical Care and Shock

SN - 1410-7767

IS - 3

ER -