Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ

Keyphrases

• Mitochondrial DNA Polymerase 100%
• Nucleoside Reverse Transcriptase Inhibitors 100%
• Human Mitochondrial DNA 100%
• Polymerase 42%
• HIV-1 Reverse Transcriptase 28%
• Low Toxicity 28%
• Order of Magnitude 28%
• Highly Active Antiretroviral Therapy (HAART) 14%
• Mitochondrial Toxicity 14%
• Active Form 14%
• Less Toxic 14%
• Emtricitabine 14%
• Triphosphate 14%
• Reverse Transcriptase Inhibitors 14%
• Biologically Active 14%
• Effective Compounds 14%
• Lamivudine 14%
• Viral Enzymes 14%
• Fluoro 14%
• Human Enzymes 14%
• Reverse Transcriptase 14%
• Structural Scaffolds 14%
• Viral DNA Synthesis 14%
• Chain Terminator 14%
• Substrate Selection 14%
• Inhibitor Specificity 14%
• Drug Selectivity 14%
• Differential Selectivity 14%

Biochemistry, Genetics and Molecular Biology

• DNA Polymerase 100%
• Nucleoside Analog Reverse Transcriptase Inhibitors 100%
• Mitochondrial DNA 100%
• Reverse Transcriptase 57%
• Polymerase 42%
• Lamivudine 28%
• DNA Synthesis 14%
• Enzyme 14%
• Enantiomer 14%
• Drug Selectivity 14%
• DNA Virus 14%
• Emtricitabine 14%

Pharmacology, Toxicology and Pharmaceutical Science

• RNA Directed DNA Polymerase Inhibitor 100%
• Mitochondrial DNA 100%
• DNA Polymerase 100%
• Nucleoside Analog 87%
• Reverse Transcriptase 37%
• Lamivudine 25%
• Mitochondrial Toxicity 12%
• Emtricitabine 12%
• Virus DNA 12%
• Drug Selectivity 12%