Probiotics and immune regulation of inflammatory bowel diseases.

Yingzi Cong, Astrid Konrad, Nuzhat Iqbal, Charles O. Elson

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Intestinal microflora play an important role in the pathogenesis of inflammatory bowel diseases (IBD). Certain probiotic bacteria provide beneficial effects for human health and intervention of IBD. Possible mechanisms underlying these effects are diverse and include many aspects of the interaction of the host with its commensal microflora, with immunological and non-immunological effects. This review paper will focus on the recent progress in the use of probiotics in the treatment of IBD, and discuss the potential immunological mechanisms underlying their effects, such as the modulation of mucosal T cell, B cell, epithelial cell, dendrtic cell, macrophage, nature killer cell, antibody, and cytokine responses.

Original languageEnglish (US)
Pages (from-to)145-154
Number of pages10
JournalCurrent drug targets. Inflammation and allergy
Volume2
Issue number2
DOIs
StatePublished - Jun 2003
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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