Production of pro-inflammatory polypeptides by airway mucous glands and its potential significance

Robert A. Cox, Ann S. Burke, Daniel L. Traber, David N. Herndon, Hal K. Hawkins

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Burn patients often develop respiratory distress and ARDS several days after injury. An ovine model allows experimental study of this problem. In sheep the injury is characterized by intense acute inflammation in the trachea and bronchi from 3 to 48 h after injury, with accumulation of neutrophils, fibrin and other plasma proteins, and mucus in airway lumens. We have carried out immunostaining for multiple cytokines in this model, including interleukin-8 (IL-8), Interleukin-1 beta (IL-1β), interleukin-1 alpha (IL-1α), tumor necrosis factor-alpha (TNF-α), and vascular endothelial growth factor (VEGF). All of these show intense immunostaining in airway mucous glands. IL-1β and VEGF show substantial constitutive staining in the serous cells of mucous glands, while IL-8, IL-1α, and TNF-α show substantially increased expression after injury. This pattern of expression of cytokines in mucous glands, and the apparent release of cytokines into the lumen after injury, are considered potentially highly significant in the progression of injury in this model. In addition, a proinflammatory function of mucous glands might prove to be important in chronic lung diseases such as chronic bronchitis and asthma.

Original languageEnglish (US)
Pages (from-to)172-177
Number of pages6
JournalPulmonary Pharmacology and Therapeutics
Volume20
Issue number2
DOIs
StatePublished - Apr 1 2007

Keywords

  • Airway
  • Bronchi
  • Bronchial circulation
  • Cytokines
  • Immunohistochemistry
  • Lung
  • Mucous glands
  • Pathology

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Biochemistry, medical
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Production of pro-inflammatory polypeptides by airway mucous glands and its potential significance'. Together they form a unique fingerprint.

  • Cite this