Production of pro-inflammatory polypeptides by airway mucous glands and its potential significance

Robert A. Cox, Ann S. Burke, Daniel L. Traber, David Herndon, Hal K. Hawkins

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Burn patients often develop respiratory distress and ARDS several days after injury. An ovine model allows experimental study of this problem. In sheep the injury is characterized by intense acute inflammation in the trachea and bronchi from 3 to 48 h after injury, with accumulation of neutrophils, fibrin and other plasma proteins, and mucus in airway lumens. We have carried out immunostaining for multiple cytokines in this model, including interleukin-8 (IL-8), Interleukin-1 beta (IL-1β), interleukin-1 alpha (IL-1α), tumor necrosis factor-alpha (TNF-α), and vascular endothelial growth factor (VEGF). All of these show intense immunostaining in airway mucous glands. IL-1β and VEGF show substantial constitutive staining in the serous cells of mucous glands, while IL-8, IL-1α, and TNF-α show substantially increased expression after injury. This pattern of expression of cytokines in mucous glands, and the apparent release of cytokines into the lumen after injury, are considered potentially highly significant in the progression of injury in this model. In addition, a proinflammatory function of mucous glands might prove to be important in chronic lung diseases such as chronic bronchitis and asthma.

Original languageEnglish (US)
Pages (from-to)172-177
Number of pages6
JournalPulmonary Pharmacology and Therapeutics
Volume20
Issue number2
DOIs
StatePublished - Apr 2007

Fingerprint

Interleukin-1beta
Cytokines
Interleukin-8
Peptides
Vascular Endothelial Growth Factor A
Wounds and Injuries
Tumor Necrosis Factor-alpha
Pulmonary diseases
Interleukin-1alpha
Fibrin
Blood Proteins
Sheep
Chronic Bronchitis
Bronchi
Mucus
Trachea
Lung Diseases
Neutrophils
Chronic Disease
Theoretical Models

Keywords

  • Airway
  • Bronchi
  • Bronchial circulation
  • Cytokines
  • Immunohistochemistry
  • Lung
  • Mucous glands
  • Pathology

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology

Cite this

Production of pro-inflammatory polypeptides by airway mucous glands and its potential significance. / Cox, Robert A.; Burke, Ann S.; Traber, Daniel L.; Herndon, David; Hawkins, Hal K.

In: Pulmonary Pharmacology and Therapeutics, Vol. 20, No. 2, 04.2007, p. 172-177.

Research output: Contribution to journalArticle

Cox, Robert A. ; Burke, Ann S. ; Traber, Daniel L. ; Herndon, David ; Hawkins, Hal K. / Production of pro-inflammatory polypeptides by airway mucous glands and its potential significance. In: Pulmonary Pharmacology and Therapeutics. 2007 ; Vol. 20, No. 2. pp. 172-177.
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