Progastrin peptides increase the risk of developing colonic tumors: Impact on colonic stem cells

Pomila Singh, Shubhashish Sarkar, Carla Kantara, Carrie Maxwell

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Preneoplastic lesions (aberrant crypt foci, hyperplastic/ dysplastic polyps) are believed to be precursors of sporadic colorectal tumors (adenomas, adenocarcinomas). Aberrant crypt foci and hyperplastic/dysplastic polyps likely originate from abnormal growth of colonic crypts in response to aberrant queues in the microenvironment of colonic crypts. Thus, identifying factors which regulate homeostatic versus aberrant proliferation/apoptosis of colonocytes, especially stem/progenitor cells, may lead to effective preventative/treatment strategies. On the basis of this philosophy, the role of growth factors/peptide hormones potentially available in the circulation/microenvironment of colonic crypts is being examined extensively. Since the time gastrins were discovered as trophic (growth) factors for gastrointestinal cells, the effect of gastrins on the growth of normal/cancer cells has been investigated, leading to many discoveries. Seminal discoveries in the area of gastrins and colon cancer as it relates to molecular pathways associated with formation of colonic tumors are reviewed and the possible impact on diagnostic/preventative/treatment strategies is discussed.

Original languageEnglish (US)
Pages (from-to)277-289
Number of pages13
JournalCurrent Colorectal Cancer Reports
Volume8
Issue number4
DOIs
StatePublished - Dec 1 2012

Keywords

  • Aberrant crypt foci
  • Adenocarcinomas
  • Adenomas
  • Akt
  • Cancer-stem cells
  • Cell-surface-associated annexin A2
  • Chromosomal instability
  • Cluster of differentiation 133
  • Cluster of differentiation 44
  • Colon carcinogenesis
  • Colonic crypts
  • Colorectal cancer
  • CpG island methylator phenotype
  • Curcumin
  • Cytochrome c oxidase subunit Vb
  • Doublecortin-Ca calmodulin kinase like protein
  • Extracellular-signalregulated kinases
  • Hyperplastic polyps
  • Janus kinase
  • Leucine-rich-repeat-containing G-protein-coupled-receptor 5
  • Microsatellite-instability
  • Nuclear factor B
  • P38 mitogen-activated protein kinase
  • Phosphoinositide 3-kinase
  • Progastrin/glycineextended gastrin
  • Rous Sarcoma viral gene encoded kinase
  • Signal transducer and activator of transcription 3
  • β;-Catenin

ASJC Scopus subject areas

  • Hepatology
  • Oncology
  • Gastroenterology

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