Progesterone reduces the inhibitory effect of a serotonin 1B receptor agonist on lordosis behavior

Lynda Uphouse, Jutatip Guptarak, Cindy Hiegel

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Ovariectomized Fischer inbred rats were hormonally primed with 10μg estradiol benzoate and sesame seed oil (EO rats) or with estradiol benzoate and 500μg progesterone (EP rats). Four to six hours after progesterone or oil, rats were pretested for sexual behavior and then infused bilaterally into the ventromedial nucleus of the hypothalamus with 0, 50, 100 or 200ng of the 5-HT1B receptor agonist, 1,4-dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-bi]pyridin-5-one-dihydrochloride (CP 93129). Sexual receptivity was monitored by the lordosis to mount (L/M) ratio. EO rats showed a transient decline in lordosis behavior following infusion with the saline vehicle and this was amplified by CP 93129. There were no effects of any infusion in EP rats. These findings are discussed in terms of the possible stress effect of the intracranial infusion in EO rats and their implications for a role of 5-HT1B receptors in the response to a mild stress.

Original languageEnglish (US)
Pages (from-to)317-324
Number of pages8
JournalPharmacology Biochemistry and Behavior
Issue number2
StatePublished - Dec 2010
Externally publishedYes


  • CP 93129
  • Hormonal priming
  • Hypothalamus
  • Intracranial infusion
  • Ovariectomized rats
  • Sexual behavior
  • Stress
  • Ventromedial nucleus

ASJC Scopus subject areas

  • Biological Psychiatry
  • Biochemistry
  • Behavioral Neuroscience
  • Clinical Biochemistry
  • Toxicology
  • Pharmacology


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