Prognosis and Treatment of Advanced Squamous Cell Carcinoma Secondary to Epidermodysplasia Verruciformis: A Worldwide Analysis of 11 Patients

T. ADAM KASPAR, RICHARD F. WAGNER, STEPHANIA JABLONSKA, MICHIHITO NIIMURA, STEPHEN K. TYRING

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Data were collected from three medical centers in the USA, Poland, and Japan regarding 11 patients with advanced squamous cell carcinoma (SCC) secondary to epidermodysplasia verruciformis (EV). Analysis was conducted regarding primary tumor location, age at onset of EV, age at diagnosis of SCC, treatment of SCC, history of local tumor recurrence, presence of metastases, and age at death. Three of 11 patients developed both lymph node and visceral metastases and the mean patient age at death was 44 years (N=6) with no patient to date living past 54 years. Mean patient survival time following metastases was 1.7 years (N = 2). Human papilloma virus typing of nine patients was performed. Current controversies regarding the treatment of patients with advanced SCC in the setting of EV are reviewed. 1991 American Society for Dermatologic Surgery, Inc.

Original languageEnglish (US)
Pages (from-to)237-240
Number of pages4
JournalThe Journal of Dermatologic Surgery and Oncology
Volume17
Issue number3
DOIs
StatePublished - Mar 1991

ASJC Scopus subject areas

  • Oncology
  • Dermatology

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