Progression of hepatic damage during cold storage after procurement in a liver and kidney donor with HELLP syndrome

Kenneth J. Woodside, A. S. Knisely, Arnold W. Strauss, Kristene Gugliuzza, John A. Daller

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background. HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome and acute fatty liver of pregnancy are associated with preeclampsia and fetal defects in fatty acid metabolism. This defect causes the accumulation of metabolites that are harmful to the maternal liver. Case Report. We report a liver and kidney donor with HELLP syndrome and describe the progression of disease in the liver during cold storage. Before procurement, liver biopsy demonstrated minimal necrosis. However, after cold storage, repeat biopsy demonstrated more than 30% necrosis. The liver was not engrafted; the kidneys were transplanted without complication. Conclusion. Livers procured from patients with HELLP syndrome should be carefully evaluated for progression of hepatic damage during cold storage and transport.

Original languageEnglish (US)
Pages (from-to)1990-1993
Number of pages4
JournalTransplantation
Volume72
Issue number12
StatePublished - 2001

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Hemolysis
Blood Platelets
Tissue Donors
Kidney
Liver
Enzymes
Necrosis
Biopsy
Pre-Eclampsia
Disease Progression
Liver Diseases
Fatty Acids
Mothers

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Progression of hepatic damage during cold storage after procurement in a liver and kidney donor with HELLP syndrome. / Woodside, Kenneth J.; Knisely, A. S.; Strauss, Arnold W.; Gugliuzza, Kristene; Daller, John A.

In: Transplantation, Vol. 72, No. 12, 2001, p. 1990-1993.

Research output: Contribution to journalArticle

Woodside, Kenneth J. ; Knisely, A. S. ; Strauss, Arnold W. ; Gugliuzza, Kristene ; Daller, John A. / Progression of hepatic damage during cold storage after procurement in a liver and kidney donor with HELLP syndrome. In: Transplantation. 2001 ; Vol. 72, No. 12. pp. 1990-1993.
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