Progressive functional adaptation of segmental bowel graft from living related donor

Enrico Benedetti, Charles Baum, Luca Cicalese, Melissa Brown, Vandad Raofi, Malek G. Massad, Herand Abcarian

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

We report a patient with short gut syndrome successfully treated with living related bowel transplantation. A 27-year-old Caucasian man was referred after traumatic loss of almost the entire bowel from the third portion of duodenum to the sigmoid colon. His HLA-identical sister volunteered as a donor. A 200-cm segment of ileum was successfully transplanted under tacrolimus-based immunosuppression. The posttransplant course was uneventful, without rejection or infectious complication. Total parenteral nutrition was discontinued 1 week posttransplant. At 6 months the patient had returned to his preinjury weight. Water and D-xylose absorption as well as fecal fat studies were markedly abnormal 1 month posttransplant but normalized by 6 months. The donor recovery was uneventful. A well-matched segmental ileal graft from living donor can provide complete rehabilitation for patients with short gut syndrome. We documented a progressive functional adaptation of the ileal graft, resulting in normal absorption by 5 months posttransplantation.

Original languageEnglish (US)
Pages (from-to)569-571
Number of pages3
JournalTransplantation
Volume71
Issue number4
DOIs
StatePublished - Feb 27 2001
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation

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