Progressive functional adaptation of segmental bowel graft from living related donor

Enrico Benedetti, Charles Baum, Luca Cicalese, Melissa Brown, Vandad Raofi, Malek G. Massad, Herand Abcarian

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We report a patient with short gut syndrome successfully treated with living related bowel transplantation. A 27-year-old Caucasian man was referred after traumatic loss of almost the entire bowel from the third portion of duodenum to the sigmoid colon. His HLA-identical sister volunteered as a donor. A 200-cm segment of ileum was successfully transplanted under tacrolimus-based immunosuppression. The posttransplant course was uneventful, without rejection or infectious complication. Total parenteral nutrition was discontinued 1 week posttransplant. At 6 months the patient had returned to his preinjury weight. Water and D-xylose absorption as well as fecal fat studies were markedly abnormal 1 month posttransplant but normalized by 6 months. The donor recovery was uneventful. A well-matched segmental ileal graft from living donor can provide complete rehabilitation for patients with short gut syndrome. We documented a progressive functional adaptation of the ileal graft, resulting in normal absorption by 5 months posttransplantation.

Original languageEnglish (US)
Pages (from-to)569-571
Number of pages3
JournalTransplantation
Volume71
Issue number4
StatePublished - Feb 27 2001
Externally publishedYes

Fingerprint

Living Donors
Transplants
Tissue Donors
Total Parenteral Nutrition
Xylose
Tacrolimus
Sigmoid Colon
Ileum
Duodenum
Immunosuppression
Siblings
Rehabilitation
Transplantation
Fats
Weights and Measures
Water
SHORT syndrome

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Benedetti, E., Baum, C., Cicalese, L., Brown, M., Raofi, V., Massad, M. G., & Abcarian, H. (2001). Progressive functional adaptation of segmental bowel graft from living related donor. Transplantation, 71(4), 569-571.

Progressive functional adaptation of segmental bowel graft from living related donor. / Benedetti, Enrico; Baum, Charles; Cicalese, Luca; Brown, Melissa; Raofi, Vandad; Massad, Malek G.; Abcarian, Herand.

In: Transplantation, Vol. 71, No. 4, 27.02.2001, p. 569-571.

Research output: Contribution to journalArticle

Benedetti, E, Baum, C, Cicalese, L, Brown, M, Raofi, V, Massad, MG & Abcarian, H 2001, 'Progressive functional adaptation of segmental bowel graft from living related donor', Transplantation, vol. 71, no. 4, pp. 569-571.
Benedetti E, Baum C, Cicalese L, Brown M, Raofi V, Massad MG et al. Progressive functional adaptation of segmental bowel graft from living related donor. Transplantation. 2001 Feb 27;71(4):569-571.
Benedetti, Enrico ; Baum, Charles ; Cicalese, Luca ; Brown, Melissa ; Raofi, Vandad ; Massad, Malek G. ; Abcarian, Herand. / Progressive functional adaptation of segmental bowel graft from living related donor. In: Transplantation. 2001 ; Vol. 71, No. 4. pp. 569-571.
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