Projections from the nucleus parafascicularis prerubralis to medullary raphe nuclei and inferior olive in the rat

A horseradish peroxidase and autoradiography study

Susan M. Carlton, George R. Leichnetz, David J. Mayer

    Research output: Contribution to journalArticle

    34 Citations (Scopus)

    Abstract

    Horseradish peroxidase gel implants into either the nucleus raphe magnus (NRM) or inferior olive (IO) led to large numbers of retrogradely labeled cells in the prerubral subthalamic region in a cell group that surrounds the fasciculus retroflexus, which we suggest should be referred to as the nucleus parafascicularis prerubralis (nPfPr) to avoid the confusion of previous terminology. Autoradiographic studies, following injections of tritiated leucine into the nPfPr, confirmed projections to both medullary raphe nuclei (MRN) and IO. This common prerubral projection to IO, a well-established precerebellar nucleus, and MRN, again raises the question of whether the latter are involved in brainstem-mediated reflexes in addition to their well documented role in analgesic mechanisms.

    Original languageEnglish (US)
    Pages (from-to)191-197
    Number of pages7
    JournalNeuroscience Letters
    Volume30
    Issue number3
    DOIs
    StatePublished - Jun 30 1982

    Fingerprint

    Intralaminar Thalamic Nuclei
    Raphe Nuclei
    Horseradish Peroxidase
    Autoradiography
    Confusion
    Terminology
    Leucine
    Brain Stem
    Reflex
    Analgesics
    Gels
    Injections
    Nucleus Raphe Magnus

    Keywords

    • autoradiography
    • horseradish peroxidase
    • inferior olive
    • nucleus parafascicularis prerubralis
    • nucleus raphe magnus
    • prerubral field
    • rat
    • red nucleu
    • subthalamus

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Projections from the nucleus parafascicularis prerubralis to medullary raphe nuclei and inferior olive in the rat : A horseradish peroxidase and autoradiography study. / Carlton, Susan M.; Leichnetz, George R.; Mayer, David J.

    In: Neuroscience Letters, Vol. 30, No. 3, 30.06.1982, p. 191-197.

    Research output: Contribution to journalArticle

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    abstract = "Horseradish peroxidase gel implants into either the nucleus raphe magnus (NRM) or inferior olive (IO) led to large numbers of retrogradely labeled cells in the prerubral subthalamic region in a cell group that surrounds the fasciculus retroflexus, which we suggest should be referred to as the nucleus parafascicularis prerubralis (nPfPr) to avoid the confusion of previous terminology. Autoradiographic studies, following injections of tritiated leucine into the nPfPr, confirmed projections to both medullary raphe nuclei (MRN) and IO. This common prerubral projection to IO, a well-established precerebellar nucleus, and MRN, again raises the question of whether the latter are involved in brainstem-mediated reflexes in addition to their well documented role in analgesic mechanisms.",
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