Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit

Megumi Kishimoto-Urata; Shinji Urata; Ryoji Kagoya; Fumiaki Imamura; Shin Nagayama; Rachel A. Reyna; Junki Maruyama; Tatsuya Yamasoba; Kenji Kondo; Sanae Hasegawa-Ishii; Slobodan Paessler

doi:10.1038/s41598-022-09731-7

Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit

Megumi Kishimoto-Urata, Shinji Urata, Ryoji Kagoya, Fumiaki Imamura, Shin Nagayama, Rachel A. Reyna, Junki Maruyama, Tatsuya Yamasoba, Kenji Kondo, Sanae Hasegawa-Ishii, Slobodan Paessler

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Abstract

The impact of SARS-CoV-2 on the olfactory pathway was studied over several time points using Syrian golden hamsters. We found an incomplete recovery of the olfactory sensory neurons, prolonged activation of glial cells in the olfactory bulb, and a decrease in the density of dendritic spines within the hippocampus. These data may be useful for elucidating the mechanism underlying long-lasting olfactory dysfunction and cognitive impairment as a post-acute COVID-19 syndrome.

Original language	English (US)
Article number	5728
Journal	Scientific reports
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41598-022-09731-7
State	Published - Dec 2022

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title = "Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit",

abstract = "The impact of SARS-CoV-2 on the olfactory pathway was studied over several time points using Syrian golden hamsters. We found an incomplete recovery of the olfactory sensory neurons, prolonged activation of glial cells in the olfactory bulb, and a decrease in the density of dendritic spines within the hippocampus. These data may be useful for elucidating the mechanism underlying long-lasting olfactory dysfunction and cognitive impairment as a post-acute COVID-19 syndrome.",

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AU - Kishimoto-Urata, Megumi

AU - Urata, Shinji

AU - Kagoya, Ryoji

AU - Imamura, Fumiaki

AU - Nagayama, Shin

AU - Reyna, Rachel A.

AU - Maruyama, Junki

AU - Yamasoba, Tatsuya

AU - Kondo, Kenji

AU - Hasegawa-Ishii, Sanae

AU - Paessler, Slobodan

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AB - The impact of SARS-CoV-2 on the olfactory pathway was studied over several time points using Syrian golden hamsters. We found an incomplete recovery of the olfactory sensory neurons, prolonged activation of glial cells in the olfactory bulb, and a decrease in the density of dendritic spines within the hippocampus. These data may be useful for elucidating the mechanism underlying long-lasting olfactory dysfunction and cognitive impairment as a post-acute COVID-19 syndrome.

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Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit

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