Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli

Hee Kee Kim, Jörn Schattschneider, Inhyung Lee, Kyungsoon Chung, Ralf Baron, Jin Chung

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This study tests the hypothesis that central sensitization initiated by nociceptive input can be maintained by repeated brief innocuous peripheral inputs. Capsaicin was injected intradermally into the hind paw of adult rats. Three different types of daily cutaneous mechanical stimulations (vibration, soft brush, or pressure) were applied to the capsaicin-injected paw for a period of 2 weeks. Daily stimulation consisted of a 10-s stimulation repeated every 30 s for 30 min. Foot withdrawal thresholds to von Frey stimuli applied to the paw were measured once a day for 4 weeks. The capsaicin-only group (control rats without daily stimulation) showed hyperalgesia lasting for 3 days. In contrast, hyperalgesia persisted for 2 weeks in the group that received vibration stimulation. Neither the soft brush nor the pressure group showed a significant difference in mechanical threshold from the control group (capsaicin only). The vibration-induced prolonged hyperalgesia was significantly reduced by systemic injection of ifenprodil, an NMDA-receptor antagonist, but it was not influenced by either an AMPA-receptor blocker or a reactive oxygen species (ROS) scavenger. Furthermore, a dorsal column lesion did not interfere with the prolongation of hyperalgesia. Data suggest that vibration-induced prolongation of hyperalgesia is mediated by spinal NMDA-receptors, and a similar mechanism may underlie some forms of chronic pain with no obvious causes, such as complex regional pain syndrome type 1 (CRPS-1).

Original languageEnglish (US)
Pages (from-to)93-101
Number of pages9
JournalPain
Volume129
Issue number1-2
DOIs
StatePublished - May 2007

Fingerprint

Capsaicin
Hyperalgesia
Vibration
Maintenance
N-Methyl-D-Aspartate Receptors
Central Nervous System Sensitization
Reflex Sympathetic Dystrophy
Pressure
Control Groups
AMPA Receptors
Chronic Pain
Foot
Reactive Oxygen Species
Skin
Injections

Keywords

  • Capsaicin
  • Central sensitization
  • Chronic pain
  • CRPS-1
  • Hyperalgesia
  • NMDA-receptor
  • Persistent pain
  • Vibration stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Neuroscience(all)
  • Pharmacology
  • Clinical Psychology

Cite this

Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli. / Kim, Hee Kee; Schattschneider, Jörn; Lee, Inhyung; Chung, Kyungsoon; Baron, Ralf; Chung, Jin.

In: Pain, Vol. 129, No. 1-2, 05.2007, p. 93-101.

Research output: Contribution to journalArticle

Kim, HK, Schattschneider, J, Lee, I, Chung, K, Baron, R & Chung, J 2007, 'Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli', Pain, vol. 129, no. 1-2, pp. 93-101. https://doi.org/10.1016/j.pain.2006.09.036
Kim, Hee Kee ; Schattschneider, Jörn ; Lee, Inhyung ; Chung, Kyungsoon ; Baron, Ralf ; Chung, Jin. / Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli. In: Pain. 2007 ; Vol. 129, No. 1-2. pp. 93-101.
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