Prolonged treatment of Menetrier's disease with an oral anticholinergic drug

R. L. Smith, D. W. Powell

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


There is considerable evidence, both in patients with Menetrier's disease and from animal models of protein-losing gastropathy, that antisecretory drugs can acutely decrease or abolish gastric plasma protein shedding. Serial measurements of serum protein components were performed in a patient with Menetrier's disease before, during, and after long term treatment with propantheline bromide. Total serum protein concentration increased significantly during the treatment period from 4.3 ± 0.50 to 5.9 ± 0.55 g per dl during treatment, while albumin increased from a pretreatment value of 2.5 ± 0.12 to 3.4 ± 0.16 g per dl. The improvement in serum proteins and symptoms continued after therapy was stopped. Intensive anticholinergic drug therapy should be tried in this disease before resorting to gastrectomy.

Original languageEnglish (US)
Pages (from-to)903-906
Number of pages4
Issue number5 PART 1
StatePublished - May 1978
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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