Promising nutritional fruits against cardiovascular diseases: An overview of experimental evidence and understanding their mechanisms of action

Nur Zulaikha Azwa Zuraini, Mahendran Sekar, Yuan Seng Wu, Siew Hua Gan, Srinivasa Reddy Bonam, Nur Najihah Izzati Mat Rani, M. Yasmin Begum, Pei Teng Lum, Vetriselvan Subramaniyan, Neeraj Kumar Fuloria, Shivkanya Fuloria

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Cardiovascular diseases (CVDs) are one of the leading causes of morbidity and mortality in both developed and developing countries, affecting millions of individuals each year. Despite the fact that successful therapeutic drugs for the management and treatment of CVDs are available on the market, nutritional fruits appear to offer the greatest benefits to the heart and have been proved to alleviate CVDs. Experimental studies have also demonstrated that nutritional fruits have potential protective effects against CVDs. The aim of the review was to provide a comprehensive summary of scientific evidence on the effect of 10 of the most commonly available nutritional fruits reported against CVDs and describe the associated mechanisms of action. Relevant literatures were searched and collected from several scientific databases including PubMed, ScienceDirect, Google Scholar and Scopus. In the context of CVDs, 10 commonly consumed nutritious fruits including apple, avocado, grapes, mango, orange, kiwi, pomegranate, papaya, pineapple, and watermelon were analysed and addressed. The cardioprotective mechanisms of the 10 nutritional fruits were also compiled and high-lighted. Overall, the present review found that the nutritious fruits and their constituents have significant benefits for the management and treatment of CVDs such as myocardial infarction, hypertension, peripheral artery disease, coronary artery disease, cardiomyopathies, dyslipide-mias, ischemic stroke, aortic aneurysm, atherosclerosis, cardiac hypertrophy and heart failure, diabetic cardiovascular complications, drug-induced cardiotoxicity and cardiomyopathy. Among the 10 nutritional fruits, pomegranate and grapes have been well explored, and the mechanisms of action are well documented against CVDs. All of the nutritional fruits men-tioned are edible and readily accessible on the market. Consuming these fruits, which may contain varying amounts of active constituents depending on the food source and season, the development of nutritious fruits-based health supplements would be more realistic for con-sistent CVD protection.

Original languageEnglish (US)
Pages (from-to)739-769
Number of pages31
JournalVascular Health and Risk Management
StatePublished - 2021
Externally publishedYes


  • Antioxidant
  • Cardiovascular diseases
  • Heart disease
  • Hypertension
  • Nutraceuticals
  • Nutritional fruits

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hematology
  • Public Health, Environmental and Occupational Health
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)


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