Prompt remission of post-renal transplant nephrotic syndrome with high-dose cyclosporine

Rajendra N. Srivastava, Alok Kalia, Luther B. Travis, Steven C. Diven, Kristene Gugliuzza, Srinivasan Rajaraman

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

A 2.8-year-old girl with focal segmental glomerulosclerosis had recurrence of nephrotic syndrome within 3 days of renal transplantation and the serum creatinine increased. Renal biopsy showed cellular rejection and also complete effacement of the epithelial cell foot processes. The rejection responded to methylprednisolone therapy but massive proteinuria persisted. An increase in the dose of cyclosporine A to 14 mg/kg per day was followed by immediate remission of the proteinuria. One month later, a second renal biopsy showed only focal fusion of foot processes. She remains free of proteinuria 2 years later. We propose that the higher dose of cyclosporine caused remission of the nephrotic syndrome.

Original languageEnglish (US)
Pages (from-to)94-95
Number of pages2
JournalPediatric Nephrology
Volume8
Issue number1
DOIs
StatePublished - Feb 1994

    Fingerprint

Keywords

  • Cyclosporine A
  • Focal segmental glomerulosclerosis
  • Recurrent nephrotic syndrome
  • Renal transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this