Prophylactic effect of low doses of human leukocyte interferon against infection with rhinovirus

S. B. Greenberg, M. W. Harmon, R. B. Couch, P. E. Johnson, S. Z. Wilson, C. C. Dacso, K. Bloom, J. Quarles

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Abstract

The prophylactic effect of low doses of human leukocyte interferon (HuIFN-a) against infection with rhinovirus was measured in double-blind, placebo-controlled studies with volunteer subjects. An antihistamine (chlorpheniramine) was given before administration of single or multiple doses of HuIFN-a by saturated cotton pledget or by aerosol; volunteers were then challenged with rhinovirus. When the results for all groups were combined, a lower frequency of respiratory illness was demonstrated in the HuIFNa-treated volunteers (20 of 39 vs. 11 of 38, P < 0.05). A significant improvement in mean symptom scores was found only in the volunteers who received HuIFN-a by cotton pledget. The total numbers of isolates of rhinovirus and seroconversions were similar for HuIFN-a-treated and control volunteers. No significant side effects were noted in the HuIFN-a-treated volunteers. Higher concentrations or improved methods of delivery of HuIFN-a will be necessary for improving the clinical efficacy of HuIFN-a against viral infections in the respiratory system.

Original languageEnglish (US)
Pages (from-to)542-546
Number of pages5
JournalJournal of Infectious Diseases
Volume145
Issue number4
DOIs
StatePublished - Apr 1982

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Greenberg, S. B., Harmon, M. W., Couch, R. B., Johnson, P. E., Wilson, S. Z., Dacso, C. C., Bloom, K., & Quarles, J. (1982). Prophylactic effect of low doses of human leukocyte interferon against infection with rhinovirus. Journal of Infectious Diseases, 145(4), 542-546. https://doi.org/10.1093/infdis/145.4.542