Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children

Tony Chao, Craig Porter, David Herndon, Aikaterina Siopi, Henry Ideker, Ronald P. Mlcak, Labros S. Sidossis, Oscar Suman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction Severe burns result in prolonged hypermetabolism and skeletal muscle catabolism. Rehabilitative exercise training (RET) programs improved muscle mass and strength in severely burned children. The combination of RET with β-blockade or testosterone analogs showed improved exercise-induced benefits on body composition and muscle function. However, the effect of RET combined with multiple drug therapy on muscle mass, strength, cardiorespiratory fitness, and protein turnover are unknown. In this placebo-controlled randomized trial, we hypothesize that RET combined with oxandrolone and propranolol (Oxprop) will improve muscle mass and function and protein turnover in severely burned children compared with burned children undergoing the same RET with a placebo. Methods We studied 42 severely burned children (7-17 yr) with severe burns over 30% of the total body surface area. Patients were randomized to placebo (22 control) or to Oxprop (20) and began drug administration within 96 h of admission. All patients began RET at hospital discharge as part of their standardized care. Muscle strength (N·m), power (W), VO 2peak, body composition, and protein fractional synthetic rate and fractional breakdown rate were measured pre-RET (PRE) and post-RET (POST). Results Muscle strength and power, lean body mass, and VO 2peak increased with RET in both groups (P < 0.01). The increase in strength and power was significantly greater in Oxprop versus control (P < 0.01), and strength and power was greater in Oxprop over control POST (P < 0.05). Fractional synthetic rate was significantly higher in Oxprop than control POST (P < 0.01), resulting in improved protein net balance POST (P < 0.05). Conclusions Rehabilitative exercise training improves body composition, muscle function, and cardiorespiratory fitness in children recovering from severe burns. Oxprop therapy augments RET-mediated improvements in muscle strength, power, and protein turnover.

Original languageEnglish (US)
Pages (from-to)427-435
Number of pages9
JournalMedicine and Science in Sports and Exercise
Volume50
Issue number3
DOIs
StatePublished - Mar 1 2018

Fingerprint

Oxandrolone
Propranolol
Exercise
Muscles
Muscle Strength
Therapeutics
Body Composition
Burns
Placebos
Proteins
Muscle Proteins
Body Surface Area

Keywords

  • BURNS
  • EXERCISE
  • OXANDROLONE
  • PEDIATRIC
  • PROPRANOLOL
  • REHABILITATION

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children. / Chao, Tony; Porter, Craig; Herndon, David; Siopi, Aikaterina; Ideker, Henry; Mlcak, Ronald P.; Sidossis, Labros S.; Suman, Oscar.

In: Medicine and Science in Sports and Exercise, Vol. 50, No. 3, 01.03.2018, p. 427-435.

Research output: Contribution to journalArticle

Chao, Tony ; Porter, Craig ; Herndon, David ; Siopi, Aikaterina ; Ideker, Henry ; Mlcak, Ronald P. ; Sidossis, Labros S. ; Suman, Oscar. / Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children. In: Medicine and Science in Sports and Exercise. 2018 ; Vol. 50, No. 3. pp. 427-435.
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AU - Chao, Tony

AU - Porter, Craig

AU - Herndon, David

AU - Siopi, Aikaterina

AU - Ideker, Henry

AU - Mlcak, Ronald P.

AU - Sidossis, Labros S.

AU - Suman, Oscar

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N2 - Introduction Severe burns result in prolonged hypermetabolism and skeletal muscle catabolism. Rehabilitative exercise training (RET) programs improved muscle mass and strength in severely burned children. The combination of RET with β-blockade or testosterone analogs showed improved exercise-induced benefits on body composition and muscle function. However, the effect of RET combined with multiple drug therapy on muscle mass, strength, cardiorespiratory fitness, and protein turnover are unknown. In this placebo-controlled randomized trial, we hypothesize that RET combined with oxandrolone and propranolol (Oxprop) will improve muscle mass and function and protein turnover in severely burned children compared with burned children undergoing the same RET with a placebo. Methods We studied 42 severely burned children (7-17 yr) with severe burns over 30% of the total body surface area. Patients were randomized to placebo (22 control) or to Oxprop (20) and began drug administration within 96 h of admission. All patients began RET at hospital discharge as part of their standardized care. Muscle strength (N·m), power (W), VO 2peak, body composition, and protein fractional synthetic rate and fractional breakdown rate were measured pre-RET (PRE) and post-RET (POST). Results Muscle strength and power, lean body mass, and VO 2peak increased with RET in both groups (P < 0.01). The increase in strength and power was significantly greater in Oxprop versus control (P < 0.01), and strength and power was greater in Oxprop over control POST (P < 0.05). Fractional synthetic rate was significantly higher in Oxprop than control POST (P < 0.01), resulting in improved protein net balance POST (P < 0.05). Conclusions Rehabilitative exercise training improves body composition, muscle function, and cardiorespiratory fitness in children recovering from severe burns. Oxprop therapy augments RET-mediated improvements in muscle strength, power, and protein turnover.

AB - Introduction Severe burns result in prolonged hypermetabolism and skeletal muscle catabolism. Rehabilitative exercise training (RET) programs improved muscle mass and strength in severely burned children. The combination of RET with β-blockade or testosterone analogs showed improved exercise-induced benefits on body composition and muscle function. However, the effect of RET combined with multiple drug therapy on muscle mass, strength, cardiorespiratory fitness, and protein turnover are unknown. In this placebo-controlled randomized trial, we hypothesize that RET combined with oxandrolone and propranolol (Oxprop) will improve muscle mass and function and protein turnover in severely burned children compared with burned children undergoing the same RET with a placebo. Methods We studied 42 severely burned children (7-17 yr) with severe burns over 30% of the total body surface area. Patients were randomized to placebo (22 control) or to Oxprop (20) and began drug administration within 96 h of admission. All patients began RET at hospital discharge as part of their standardized care. Muscle strength (N·m), power (W), VO 2peak, body composition, and protein fractional synthetic rate and fractional breakdown rate were measured pre-RET (PRE) and post-RET (POST). Results Muscle strength and power, lean body mass, and VO 2peak increased with RET in both groups (P < 0.01). The increase in strength and power was significantly greater in Oxprop versus control (P < 0.01), and strength and power was greater in Oxprop over control POST (P < 0.05). Fractional synthetic rate was significantly higher in Oxprop than control POST (P < 0.01), resulting in improved protein net balance POST (P < 0.05). Conclusions Rehabilitative exercise training improves body composition, muscle function, and cardiorespiratory fitness in children recovering from severe burns. Oxprop therapy augments RET-mediated improvements in muscle strength, power, and protein turnover.

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KW - REHABILITATION

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