Propranolol improves impaired hepatic phosphatidylinositol 3-kinase/akt signaling after burn injury.

Natasha C. Brooks, Juquan Song, Darren Boehning, Robert Kraft, Celeste Finnerty, David Herndon, Marc G. Jeschke

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Severe burn injury is associated with induction of the hepatic endoplasmic reticulum (ER) stress response. ER stress leads to activation of c-Jun N-terminal kinase (JNK), suppression of insulin receptor signaling via phosphorylation of insulin receptor substrate 1 and subsequent insulin resistance. Marked and sustained increases in catecholamines are prominent after a burn. Here, we show that administration of propranolol, a nonselective β1/2 adrenergic receptor antagonist, attenuates ER stress and JNK activation. Attenuation of ER stress by propranolol results in increased insulin sensitivity, as determined by activation of hepatic phosphatidylinositol 3-kinase and Akt. We conclude that catecholamine release is responsible for the ER stress response and impaired insulin receptor signaling after burn injury.

Original languageEnglish (US)
Pages (from-to)707-711
Number of pages5
JournalMolecular medicine (Cambridge, Mass.)
Volume18
StatePublished - 2012
Externally publishedYes

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Phosphatidylinositol 3-Kinase
Endoplasmic Reticulum Stress
Propranolol
Liver
Wounds and Injuries
Insulin Receptor
Catecholamines
Insulin Resistance
Insulin Receptor Substrate Proteins
Adrenergic Antagonists
JNK Mitogen-Activated Protein Kinases
Phosphotransferases
Phosphorylation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Propranolol improves impaired hepatic phosphatidylinositol 3-kinase/akt signaling after burn injury. / Brooks, Natasha C.; Song, Juquan; Boehning, Darren; Kraft, Robert; Finnerty, Celeste; Herndon, David; Jeschke, Marc G.

In: Molecular medicine (Cambridge, Mass.), Vol. 18, 2012, p. 707-711.

Research output: Contribution to journalArticle

Brooks, Natasha C. ; Song, Juquan ; Boehning, Darren ; Kraft, Robert ; Finnerty, Celeste ; Herndon, David ; Jeschke, Marc G. / Propranolol improves impaired hepatic phosphatidylinositol 3-kinase/akt signaling after burn injury. In: Molecular medicine (Cambridge, Mass.). 2012 ; Vol. 18. pp. 707-711.
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