Propranolol Reduces Cardiac Index But Does Not Adversely Affect Peripheral Perfusion in Severely Burned Children

Paul Wurzer, Ludwik Branski, Robert P. Clayton, Gabriel Hundeshagen, Abigail A. Forbes, Charles D. Voigt, Clark R. Andersen, Lars P. Kamolz, Lee C. Woodson, Oscar Suman, Celeste Finnerty, David Herndon

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

PURPOSE:: The aim of this study was to quantify the effect of propranolol on hemodynamic parameters assessed using the PiCCO system in burned children. METHODS:: We analyzed hemodynamic data from patients who were randomized to receive either propranolol (4?mg/kg/day) or placebo (control), which was initiated as a prospective randomized controlled trial. Endpoints were cardiac index (CI), percent predicted heart rate (%HR), mean arterial pressure (MAP), percent predicted stroke volume (%SV), rate pressure product (RPP), cardiac work (CW), systemic vascular resistance index (SVRI), extravascular lung water index (EVLWI), arterial blood gases, events of lactic acidosis, and mortality. Mixed multiple linear regressions were applied, and a 95% level of confidence was assumed. RESULTS:: One hundred twenty-one burned children (control: N?=?62, propranolol: N?=?59) were analyzed. Groups were comparable in demographics, EVLWI, SVRI, %SV, arterial blood gases, Denver 2 post injury organ failure score, incidence of lactic acidosis, or mortality. Percent predicted HR, MAP, CI, CW, and RPP were significantly reduced in the propranolol-treated group (p?

Original languageEnglish (US)
JournalShock
DOIs
StateAccepted/In press - Jul 1 2016

Fingerprint

Propranolol
Perfusion
Extravascular Lung Water
Lactic Acidosis
Vascular Resistance
Arterial Pressure
Gases
Hemodynamics
Organ Dysfunction Scores
Pressure
Mortality
Stroke Volume
Linear Models
Randomized Controlled Trials
Heart Rate
Placebos
Demography
Incidence
Wounds and Injuries

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine

Cite this

Propranolol Reduces Cardiac Index But Does Not Adversely Affect Peripheral Perfusion in Severely Burned Children. / Wurzer, Paul; Branski, Ludwik; Clayton, Robert P.; Hundeshagen, Gabriel; Forbes, Abigail A.; Voigt, Charles D.; Andersen, Clark R.; Kamolz, Lars P.; Woodson, Lee C.; Suman, Oscar; Finnerty, Celeste; Herndon, David.

In: Shock, 01.07.2016.

Research output: Contribution to journalArticle

Wurzer, Paul ; Branski, Ludwik ; Clayton, Robert P. ; Hundeshagen, Gabriel ; Forbes, Abigail A. ; Voigt, Charles D. ; Andersen, Clark R. ; Kamolz, Lars P. ; Woodson, Lee C. ; Suman, Oscar ; Finnerty, Celeste ; Herndon, David. / Propranolol Reduces Cardiac Index But Does Not Adversely Affect Peripheral Perfusion in Severely Burned Children. In: Shock. 2016.
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abstract = "PURPOSE:: The aim of this study was to quantify the effect of propranolol on hemodynamic parameters assessed using the PiCCO system in burned children. METHODS:: We analyzed hemodynamic data from patients who were randomized to receive either propranolol (4?mg/kg/day) or placebo (control), which was initiated as a prospective randomized controlled trial. Endpoints were cardiac index (CI), percent predicted heart rate ({\%}HR), mean arterial pressure (MAP), percent predicted stroke volume ({\%}SV), rate pressure product (RPP), cardiac work (CW), systemic vascular resistance index (SVRI), extravascular lung water index (EVLWI), arterial blood gases, events of lactic acidosis, and mortality. Mixed multiple linear regressions were applied, and a 95{\%} level of confidence was assumed. RESULTS:: One hundred twenty-one burned children (control: N?=?62, propranolol: N?=?59) were analyzed. Groups were comparable in demographics, EVLWI, SVRI, {\%}SV, arterial blood gases, Denver 2 post injury organ failure score, incidence of lactic acidosis, or mortality. Percent predicted HR, MAP, CI, CW, and RPP were significantly reduced in the propranolol-treated group (p?",
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AU - Hundeshagen, Gabriel

AU - Forbes, Abigail A.

AU - Voigt, Charles D.

AU - Andersen, Clark R.

AU - Kamolz, Lars P.

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AU - Herndon, David

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