Propranolol Reduces Cardiac Index But Does Not Adversely Affect Peripheral Perfusion in Severely Burned Children

Paul Wurzer, Ludwik Branski, Robert P. Clayton, Gabriel Hundeshagen, Abigail A. Forbes, Charles D. Voigt, Clark R. Andersen, Lars P. Kamolz, Lee C. Woodson, Oscar Suman, Celeste Finnerty, David Herndon

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6 Scopus citations

Abstract

PURPOSE:: The aim of this study was to quantify the effect of propranolol on hemodynamic parameters assessed using the PiCCO system in burned children. METHODS:: We analyzed hemodynamic data from patients who were randomized to receive either propranolol (4?mg/kg/day) or placebo (control), which was initiated as a prospective randomized controlled trial. Endpoints were cardiac index (CI), percent predicted heart rate (%HR), mean arterial pressure (MAP), percent predicted stroke volume (%SV), rate pressure product (RPP), cardiac work (CW), systemic vascular resistance index (SVRI), extravascular lung water index (EVLWI), arterial blood gases, events of lactic acidosis, and mortality. Mixed multiple linear regressions were applied, and a 95% level of confidence was assumed. RESULTS:: One hundred twenty-one burned children (control: N?=?62, propranolol: N?=?59) were analyzed. Groups were comparable in demographics, EVLWI, SVRI, %SV, arterial blood gases, Denver 2 post injury organ failure score, incidence of lactic acidosis, or mortality. Percent predicted HR, MAP, CI, CW, and RPP were significantly reduced in the propranolol-treated group (p?

Original languageEnglish (US)
JournalShock
DOIs
StateAccepted/In press - Jul 1 2016

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ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine

Cite this

Wurzer, P., Branski, L., Clayton, R. P., Hundeshagen, G., Forbes, A. A., Voigt, C. D., Andersen, C. R., Kamolz, L. P., Woodson, L. C., Suman, O., Finnerty, C., & Herndon, D. (Accepted/In press). Propranolol Reduces Cardiac Index But Does Not Adversely Affect Peripheral Perfusion in Severely Burned Children. Shock. https://doi.org/10.1097/SHK.0000000000000671