Prospects for a virus non-structural protein as a subunit vaccine

Carl A. Gibson, Jacob J. Schlesinger, Alan Barrett

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The design of contemporary vaccines to date has been dependent upon our understanding of the process of stimulation of protective immunity by virion proteins. However, studies with the flaviviruses have demonstrated that protective immunity can be elicited by a non-structural protein, NS1. Surprisingly, immunity to infection is stimulated in the absence of neutralizing antibodies. The information concerning NS1-induced immunity is described and is discussed with relevance to the role of the protein in immunity and vaccine development, against flavivirus diseases. The possibility exists that the phenomenon of non-structural protein induced immunity is applicable to the prophylaxis of other virus diseases.

Original languageEnglish (US)
Pages (from-to)7-9
Number of pages3
JournalVaccine
Volume6
Issue number1
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Viral Structural Proteins
Subunit Vaccines
subunit vaccines
Immunity
immunity
viruses
Flavivirus
proteins
Proteins
Vaccines
Flaviviridae
vaccine development
Virus Diseases
Neutralizing Antibodies
virion
neutralizing antibodies
Virion
disease control
vaccines
Infection

Keywords

  • Flavivirus
  • immunity
  • non-structural protein

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Prospects for a virus non-structural protein as a subunit vaccine. / Gibson, Carl A.; Schlesinger, Jacob J.; Barrett, Alan.

In: Vaccine, Vol. 6, No. 1, 1988, p. 7-9.

Research output: Contribution to journalArticle

Gibson, Carl A. ; Schlesinger, Jacob J. ; Barrett, Alan. / Prospects for a virus non-structural protein as a subunit vaccine. In: Vaccine. 1988 ; Vol. 6, No. 1. pp. 7-9.
@article{288afe32561a4d268a28668ba3c474f1,
title = "Prospects for a virus non-structural protein as a subunit vaccine",
abstract = "The design of contemporary vaccines to date has been dependent upon our understanding of the process of stimulation of protective immunity by virion proteins. However, studies with the flaviviruses have demonstrated that protective immunity can be elicited by a non-structural protein, NS1. Surprisingly, immunity to infection is stimulated in the absence of neutralizing antibodies. The information concerning NS1-induced immunity is described and is discussed with relevance to the role of the protein in immunity and vaccine development, against flavivirus diseases. The possibility exists that the phenomenon of non-structural protein induced immunity is applicable to the prophylaxis of other virus diseases.",
keywords = "Flavivirus, immunity, non-structural protein",
author = "Gibson, {Carl A.} and Schlesinger, {Jacob J.} and Alan Barrett",
year = "1988",
doi = "10.1016/0264-410X(88)90004-7",
language = "English (US)",
volume = "6",
pages = "7--9",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Prospects for a virus non-structural protein as a subunit vaccine

AU - Gibson, Carl A.

AU - Schlesinger, Jacob J.

AU - Barrett, Alan

PY - 1988

Y1 - 1988

N2 - The design of contemporary vaccines to date has been dependent upon our understanding of the process of stimulation of protective immunity by virion proteins. However, studies with the flaviviruses have demonstrated that protective immunity can be elicited by a non-structural protein, NS1. Surprisingly, immunity to infection is stimulated in the absence of neutralizing antibodies. The information concerning NS1-induced immunity is described and is discussed with relevance to the role of the protein in immunity and vaccine development, against flavivirus diseases. The possibility exists that the phenomenon of non-structural protein induced immunity is applicable to the prophylaxis of other virus diseases.

AB - The design of contemporary vaccines to date has been dependent upon our understanding of the process of stimulation of protective immunity by virion proteins. However, studies with the flaviviruses have demonstrated that protective immunity can be elicited by a non-structural protein, NS1. Surprisingly, immunity to infection is stimulated in the absence of neutralizing antibodies. The information concerning NS1-induced immunity is described and is discussed with relevance to the role of the protein in immunity and vaccine development, against flavivirus diseases. The possibility exists that the phenomenon of non-structural protein induced immunity is applicable to the prophylaxis of other virus diseases.

KW - Flavivirus

KW - immunity

KW - non-structural protein

UR - http://www.scopus.com/inward/record.url?scp=0023833739&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023833739&partnerID=8YFLogxK

U2 - 10.1016/0264-410X(88)90004-7

DO - 10.1016/0264-410X(88)90004-7

M3 - Article

VL - 6

SP - 7

EP - 9

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 1

ER -