Prostaglandin E inhibition of mitogen stimulation in patients with multiple sclerosis

James S. Goodwin, Ronald P. Messner

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Kirbey et al have reported that leukocyte function from patients with multiple sclerosis is not suppressed by PGE2, as are normal leukocytes. We examined the ability of PGE2 (0.01-0.5 μg/ml) to suppress Phytohemagglutinin induced 3H-thymidine incorporation in peripheral blood lymphocytes from multiple sclerosis patients and normals. There was no difference in sensitivity between the two groups. There was also no difference in activity of the prostaglandin producing suppressor cell between the multiple sclerosis patients and controls.

Original languageEnglish (US)
Pages (from-to)281-286
Number of pages6
JournalProstaglandins
Volume15
Issue number2
DOIs
StatePublished - Feb 1978
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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