Prostaglandin E inhibition of mitogen stimulation in patients with multiple sclerosis

James S. Goodwin; Ronald P. Messner

doi:10.1016/0090-6980(78)90167-3

Prostaglandin E inhibition of mitogen stimulation in patients with multiple sclerosis

James S. Goodwin, Ronald P. Messner

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Kirbey et al have reported that leukocyte function from patients with multiple sclerosis is not suppressed by PGE₂, as are normal leukocytes. We examined the ability of PGE₂ (0.01-0.5 μg/ml) to suppress Phytohemagglutinin induced ³H-thymidine incorporation in peripheral blood lymphocytes from multiple sclerosis patients and normals. There was no difference in sensitivity between the two groups. There was also no difference in activity of the prostaglandin producing suppressor cell between the multiple sclerosis patients and controls.

Original language	English (US)
Pages (from-to)	281-286
Number of pages	6
Journal	Prostaglandins
Volume	15
Issue number	2
DOIs	https://doi.org/10.1016/0090-6980(78)90167-3
State	Published - Feb 1978
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Endocrinology

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title = "Prostaglandin E inhibition of mitogen stimulation in patients with multiple sclerosis",

abstract = "Kirbey et al have reported that leukocyte function from patients with multiple sclerosis is not suppressed by PGE2, as are normal leukocytes. We examined the ability of PGE2 (0.01-0.5 μg/ml) to suppress Phytohemagglutinin induced 3H-thymidine incorporation in peripheral blood lymphocytes from multiple sclerosis patients and normals. There was no difference in sensitivity between the two groups. There was also no difference in activity of the prostaglandin producing suppressor cell between the multiple sclerosis patients and controls.",

author = "Goodwin, {James S.} and Messner, {Ronald P.}",

note = "Funding Information: i. Dr. Goodwin is a Research Fellow of the Arthritis Foundation. This work was supported in part by a grant (AM 13787-07) from the U.S. Public Health Service. Reprint requests should be addressed to Dr. Goodwin.",

year = "1978",

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doi = "10.1016/0090-6980(78)90167-3",

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T1 - Prostaglandin E inhibition of mitogen stimulation in patients with multiple sclerosis

AU - Goodwin, James S.

AU - Messner, Ronald P.

N1 - Funding Information: i. Dr. Goodwin is a Research Fellow of the Arthritis Foundation. This work was supported in part by a grant (AM 13787-07) from the U.S. Public Health Service. Reprint requests should be addressed to Dr. Goodwin.

PY - 1978/2

Y1 - 1978/2

N2 - Kirbey et al have reported that leukocyte function from patients with multiple sclerosis is not suppressed by PGE2, as are normal leukocytes. We examined the ability of PGE2 (0.01-0.5 μg/ml) to suppress Phytohemagglutinin induced 3H-thymidine incorporation in peripheral blood lymphocytes from multiple sclerosis patients and normals. There was no difference in sensitivity between the two groups. There was also no difference in activity of the prostaglandin producing suppressor cell between the multiple sclerosis patients and controls.

AB - Kirbey et al have reported that leukocyte function from patients with multiple sclerosis is not suppressed by PGE2, as are normal leukocytes. We examined the ability of PGE2 (0.01-0.5 μg/ml) to suppress Phytohemagglutinin induced 3H-thymidine incorporation in peripheral blood lymphocytes from multiple sclerosis patients and normals. There was no difference in sensitivity between the two groups. There was also no difference in activity of the prostaglandin producing suppressor cell between the multiple sclerosis patients and controls.

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ER -

Prostaglandin E inhibition of mitogen stimulation in patients with multiple sclerosis

Abstract

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