Prostaglandin E1 analogues misoprostol and enisoprost decrease microbial translocation and modulate the immune response

L. Gianotti, J. W. Alexander, T. Pyles, R. Fukushima, G. F. Babcock

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The aim of this study was to investigate the ability of two prostaglandin E1 (PGE1) analogues, misoprostol and enisoprost, to alter bacterial translocation following burn injury. Balb/c mice were treated with misoprostol (n = 36) or enisoprost (n = 36) for 3 days with different doses (20 or 200 μg/kg/day) prior to receiving a 20% full-thickness burn and simultaneous gavage with 1 x 1010 14C-Escherichia coli. Animals were sacrificed 4 and 24 hr postburn, and blood, peritoneal fluid, mesenteric lymph nodes, spleen, liver, and lungs were harvested aseptically. Radionuclide counts, number of viable bacteria, and percentage of translocating bacteria remaining alive in each tissue suggested that the high doses of misoprostol or enisoprost decreased the magnitude of 14C-E. coli translocation, while the low dose of both drugs enhanced bacterial clearance. Therefore, both misoprostol and enisoprost reduce bacterial translocation, and modulate bacterial clearance in a dose-dependent manner.

Original languageEnglish (US)
Pages (from-to)243-249
Number of pages7
JournalCirculatory Shock
Volume40
Issue number4
StatePublished - 1993

Keywords

  • C-labeled Escherichia coli
  • Escherichia coli
  • Intestinal function
  • burn injury
  • endotoxin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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