Prostate cancer brain metastases: Monitoring response to treatment with PSMA PET/CT

Anas Al-Zubaidi; Samuel Bezold; Peeyush Bhargava; Javier Villanueva-Meyer

doi:10.1016/j.radcr.2024.02.110

Prostate cancer brain metastases: Monitoring response to treatment with PSMA PET/CT

Anas Al-Zubaidi, Samuel Bezold, Peeyush Bhargava, Javier Villanueva-Meyer

Radiology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Prostate cancer brain metastases are rare but increasingly recognized with prostate-specific membrane antigen (PSMA) PET/CT. Distinguishing tumor response from postradiation changes are challenging on MRI. PSMA PET/CT may clarify equivocal brain lesions after radiotherapy. A 71-year-old man with metastatic prostate cancer developed 2 new brain lesions on PSMA PET/CT. Lesions were high PSMA-avid and MRI follow up showed enhancing masses with edema, consistent with metastases. He underwent whole-brain radiation. Follow-up PSMA PET/CT after radiotherapy demonstrated significantly decreased lesion size and activity, with activity lower than blood pool, indicating a treatment response. MRI also showed near-resolution of the lesions. This case highlights the potential utility of PSMA PET/CT for detecting prostate cancer brain metastases and monitoring treatment response. PSMA PET/CT provides valuable complementary information to MRI for managing irradiated prostate cancer brain metastases.

Original language	English (US)
Pages (from-to)	2367-2370
Number of pages	4
Journal	Radiology Case Reports
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/j.radcr.2024.02.110
State	Published - Jun 2024

Keywords

Brain metastasis
Prostate cancer
PSMA PET/CT
Radiation therapy

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1016/j.radcr.2024.02.110

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title = "Prostate cancer brain metastases: Monitoring response to treatment with PSMA PET/CT",

abstract = "Prostate cancer brain metastases are rare but increasingly recognized with prostate-specific membrane antigen (PSMA) PET/CT. Distinguishing tumor response from postradiation changes are challenging on MRI. PSMA PET/CT may clarify equivocal brain lesions after radiotherapy. A 71-year-old man with metastatic prostate cancer developed 2 new brain lesions on PSMA PET/CT. Lesions were high PSMA-avid and MRI follow up showed enhancing masses with edema, consistent with metastases. He underwent whole-brain radiation. Follow-up PSMA PET/CT after radiotherapy demonstrated significantly decreased lesion size and activity, with activity lower than blood pool, indicating a treatment response. MRI also showed near-resolution of the lesions. This case highlights the potential utility of PSMA PET/CT for detecting prostate cancer brain metastases and monitoring treatment response. PSMA PET/CT provides valuable complementary information to MRI for managing irradiated prostate cancer brain metastases.",

keywords = "Brain metastasis, Prostate cancer, PSMA PET/CT, Radiation therapy",

author = "Anas Al-Zubaidi and Samuel Bezold and Peeyush Bhargava and Javier Villanueva-Meyer",

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year = "2024",

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doi = "10.1016/j.radcr.2024.02.110",

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AU - Al-Zubaidi, Anas

AU - Bezold, Samuel

AU - Bhargava, Peeyush

AU - Villanueva-Meyer, Javier

PY - 2024/6

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N2 - Prostate cancer brain metastases are rare but increasingly recognized with prostate-specific membrane antigen (PSMA) PET/CT. Distinguishing tumor response from postradiation changes are challenging on MRI. PSMA PET/CT may clarify equivocal brain lesions after radiotherapy. A 71-year-old man with metastatic prostate cancer developed 2 new brain lesions on PSMA PET/CT. Lesions were high PSMA-avid and MRI follow up showed enhancing masses with edema, consistent with metastases. He underwent whole-brain radiation. Follow-up PSMA PET/CT after radiotherapy demonstrated significantly decreased lesion size and activity, with activity lower than blood pool, indicating a treatment response. MRI also showed near-resolution of the lesions. This case highlights the potential utility of PSMA PET/CT for detecting prostate cancer brain metastases and monitoring treatment response. PSMA PET/CT provides valuable complementary information to MRI for managing irradiated prostate cancer brain metastases.

AB - Prostate cancer brain metastases are rare but increasingly recognized with prostate-specific membrane antigen (PSMA) PET/CT. Distinguishing tumor response from postradiation changes are challenging on MRI. PSMA PET/CT may clarify equivocal brain lesions after radiotherapy. A 71-year-old man with metastatic prostate cancer developed 2 new brain lesions on PSMA PET/CT. Lesions were high PSMA-avid and MRI follow up showed enhancing masses with edema, consistent with metastases. He underwent whole-brain radiation. Follow-up PSMA PET/CT after radiotherapy demonstrated significantly decreased lesion size and activity, with activity lower than blood pool, indicating a treatment response. MRI also showed near-resolution of the lesions. This case highlights the potential utility of PSMA PET/CT for detecting prostate cancer brain metastases and monitoring treatment response. PSMA PET/CT provides valuable complementary information to MRI for managing irradiated prostate cancer brain metastases.

KW - Brain metastasis

KW - Prostate cancer

KW - PSMA PET/CT

KW - Radiation therapy

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Prostate cancer brain metastases: Monitoring response to treatment with PSMA PET/CT

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Keywords

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