Protecting skeletal muscle with protein and amino acid during periods of disuse

Elfego Galvan, Emily Arentson-Lantz, Séverine Lamon, Douglas Paddon-Jones

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Habitual sedentary behavior increases risk of chronic disease, hospitalization and poor quality of life. Short-term bed rest or disuse accelerates the loss of muscle mass, function, and glucose tolerance. Optimizing nutritional practices and protein intake may reduce the consequences of disuse by preserving metabolic homeostasis and muscle mass and function. Most modes of physical inactivity have the potential to negatively impact the health of older adults more than their younger counterparts. Mechanistically, mammalian target of rapamycin complex 1 (mTORC1) signaling and muscle protein synthesis are negatively affected by disuse. This contributes to reduced muscle quality and is accompanied by impaired glucose regulation. Simply encouraging increased protein and/or energy consumption is a well-intentioned, but often impractical strategy to protect muscle health. Emerging evidence suggests that leucine supplemented meals may partially and temporarily protect skeletal muscle during disuse by preserving anabolism and mitigating reductions in mass, function and metabolic homeostasis.

Original languageEnglish (US)
Article number404
JournalNutrients
Volume8
Issue number7
DOIs
StatePublished - Jul 1 2016

Fingerprint

Muscle Proteins
skeletal muscle
Skeletal Muscle
Amino Acids
Muscles
muscles
amino acids
homeostasis
Homeostasis
proteins
Glucose
Bed Rest
Health
muscle protein
glucose tolerance
Risk-Taking
protein intake
quality of life
chronic diseases
Leucine

Keywords

  • Bed rest
  • Diet
  • Inactivity
  • Leucine
  • Muscle health
  • Muscle protein synthesis

ASJC Scopus subject areas

  • Food Science

Cite this

Protecting skeletal muscle with protein and amino acid during periods of disuse. / Galvan, Elfego; Arentson-Lantz, Emily; Lamon, Séverine; Paddon-Jones, Douglas.

In: Nutrients, Vol. 8, No. 7, 404, 01.07.2016.

Research output: Contribution to journalReview article

Galvan, Elfego ; Arentson-Lantz, Emily ; Lamon, Séverine ; Paddon-Jones, Douglas. / Protecting skeletal muscle with protein and amino acid during periods of disuse. In: Nutrients. 2016 ; Vol. 8, No. 7.
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