Protection against Japanese encephalitis virus strains representing four genotypes by passive transfer of sera raised against ChimeriVax™-JE experimental vaccine

David W.C. Beasley, Li Li, Miguel T. Suderman, Farshad Guirakhoo, Dennis W. Trent, Thomas P. Monath, Robert E. Shope, Alan D.T. Barrett

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

The ability of antisera raised against a candidate Japanese encephalitis virus (JEV) vaccine, ChimeriVax™-JE, and the currently licensed vaccine, JE-VAX®, to protect against strains of JEV representing the four major genotypes was assessed. Neutralization assays and passive protection studies in mice showed that greatest protection was provided against strains of genotypes II and III, although some protection was also afforded against genotypes I and IV strains. ChimeriVax™-JE stimulated protection that was comparable or superior to the JE-VAX® control.

Original languageEnglish (US)
Pages (from-to)3722-3726
Number of pages5
JournalVaccine
Volume22
Issue number27-28
DOIs
StatePublished - Sep 9 2004

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Keywords

  • ChimeriVax™-JE
  • Genotype
  • Japanese encephalitis virus

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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