Protection against Japanese encephalitis virus strains representing four genotypes by passive transfer of sera raised against ChimeriVax™-JE experimental vaccine

David W.C. Beasley; Li Li; Miguel T. Suderman; Farshad Guirakhoo; Dennis W. Trent; Thomas P. Monath; Robert E. Shope; Alan D.T. Barrett

doi:10.1016/j.vaccine.2004.03.027

Protection against Japanese encephalitis virus strains representing four genotypes by passive transfer of sera raised against ChimeriVax™-JE experimental vaccine

David W.C. Beasley, Li Li, Miguel T. Suderman, Farshad Guirakhoo, Dennis W. Trent, Thomas P. Monath, Robert E. Shope, Alan D.T. Barrett

Research output: Contribution to journal › Article

55 Scopus citations

Abstract

The ability of antisera raised against a candidate Japanese encephalitis virus (JEV) vaccine, ChimeriVax™-JE, and the currently licensed vaccine, JE-VAX^®, to protect against strains of JEV representing the four major genotypes was assessed. Neutralization assays and passive protection studies in mice showed that greatest protection was provided against strains of genotypes II and III, although some protection was also afforded against genotypes I and IV strains. ChimeriVax™-JE stimulated protection that was comparable or superior to the JE-VAX^® control.

Original language	English (US)
Pages (from-to)	3722-3726
Number of pages	5
Journal	Vaccine
Volume	22
Issue number	27-28
DOIs	https://doi.org/10.1016/j.vaccine.2004.03.027
State	Published - Sep 9 2004

Keywords

ChimeriVax™-JE
Genotype
Japanese encephalitis virus

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

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Beasley, D. W. C., Li, L., Suderman, M. T., Guirakhoo, F., Trent, D. W., Monath, T. P., Shope, R. E., & Barrett, A. D. T. (2004). Protection against Japanese encephalitis virus strains representing four genotypes by passive transfer of sera raised against ChimeriVax™-JE experimental vaccine. Vaccine, 22(27-28), 3722-3726. https://doi.org/10.1016/j.vaccine.2004.03.027

Protection against Japanese encephalitis virus strains representing four genotypes by passive transfer of sera raised against ChimeriVax™-JE experimental vaccine. / Beasley, David W.C.; Li, Li; Suderman, Miguel T.; Guirakhoo, Farshad; Trent, Dennis W.; Monath, Thomas P.; Shope, Robert E.; Barrett, Alan D.T.

In: Vaccine, Vol. 22, No. 27-28, 09.09.2004, p. 3722-3726.

Research output: Contribution to journal › Article

Beasley, David W.C. ; Li, Li ; Suderman, Miguel T. ; Guirakhoo, Farshad ; Trent, Dennis W. ; Monath, Thomas P. ; Shope, Robert E. ; Barrett, Alan D.T. / Protection against Japanese encephalitis virus strains representing four genotypes by passive transfer of sera raised against ChimeriVax™-JE experimental vaccine. In: Vaccine. 2004 ; Vol. 22, No. 27-28. pp. 3722-3726.

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abstract = "The ability of antisera raised against a candidate Japanese encephalitis virus (JEV) vaccine, ChimeriVax{\texttrademark}-JE, and the currently licensed vaccine, JE-VAX{\textregistered}, to protect against strains of JEV representing the four major genotypes was assessed. Neutralization assays and passive protection studies in mice showed that greatest protection was provided against strains of genotypes II and III, although some protection was also afforded against genotypes I and IV strains. ChimeriVax{\texttrademark}-JE stimulated protection that was comparable or superior to the JE-VAX{\textregistered} control.",

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